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Faculty

Nelson Chao

Professor of Medicine, Immunology, Pathology and Global Health
School of Medicine
Medicine: Cellular Therapy

DUMC 3961, Durham, NC 27710
(919) 668-1011
chao0002@mc.duke.edu

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Nelson Chao

Summary

My research interests are in two broad areas, clinical hematopoietic stem cell and cord blood transplantation and in the laboratory studies related to graft vs. host disease and immune reconstitution. On the clinical side we are currently conducting approximately 50 different clinical protocols ranging from preparatory regimens, supportive care studies and disease specific protocols. Most of these clinical studies are centered around studies of the sources of stem cells and the methods to improve the long term outcome. There are exploratory protocols for novel therapies such as dendritic cell therapy for several malignancies, antiangiogenesis therapy, graft engineering to prevent graft-versus-host disease and antigen specific T cells or non specific NK cells to prevent relapse. Moreover a strong focus of the program is to develop cord-blood transplantation for adult patients with hematologic malignancies. The laboratory studies center on understanding the immunological events that occur with graft-vs-host disease and methods to prevent this disease. The current efforts focus on understanding murine reconstitution following transplantation, use of a peptide polymer to block MHC class II recognition of minor histocompatibility antigens, use of T cell engineering to prevent graft-versus-host disease at the same time preserving a graft-versus-malignancy effect.

Locations

Projects

Recent Publications

Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms Heather A Himburg, Phuong L Doan, Mamle Quarmyne, Xiao Yan, Joshua Sasine, Liman Zhao, Grace V Hancock, Jenny Kan, Katherine A Pohl, Evelyn Tran, Nelson J Chao, Jeffrey R Harris & John P Chute View

Why Patient-Centric Care WorksNelson Jen An Chao, M.D., MBA, and Krista Rowe-Nichols RN, MSN. View

Establishing global health cancer care partnerships across common ground: bridging nuclear security, equitable access, education, outreach, and mentorshipC Norman Coleman, MD, Silvia C Formenti, MD, Nelson Chao, MD, Surbhi Grover, MD, Danielle Rodin, MD, Daniel G Petereit, MD, Bhadrasain Vikram, MD, David A Pistenmaa, MD, Majid Mohiuddin, MD, Tim R Williams, MD, Nina Wendling, PhD, Lawrence Roth, MBA, Mary Gospodarowicz, MD, D Jaffray, PhD View

Myeloablative conditioning with total body irradiation for AML: Balancing survival and pulmonary toxicity Sarah J. Stephens, MD, Samantha Thomas, MB, David A. Rizzieri, MD, Mitchell E. Horwitz, MD, Nelson J. Chao, MD, Ashley M. Engemann, PharmD, Martha Lassiter, MSN, Chris R. Kelsey, MD, View

Advanced Practice Provider Skills Day: Improving Compliance and Standardizing CareKerry King Minor, ANP-BC, Anderson Garrett, AGPCNP, Nelson J. Chao, MD, MBA, Therese Hennig, PA-C View

Radiation Needs In Pediatric Oncology in the Lake Region Of TanzaniaKristin Schroeder, Adam C. Olson, Brad Ackerson, Nicole Larrier, Nestory Masalu, Nelson Chao, Beda Likonda View

Chao, N. J. and Confer, D. L. (2015) The Role of the Transplant Program in a Nuclear Accident or Terrorism, in Thomas’ Hematopoietic Cell Transplantation, Fifth Edition (eds S. J. Forman, R. S. Negrin, J. H. Antin and F. R. Appelbaum), John Wiley & Sons, Ltd, Chichester, UK. View

Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery Michael M. B. Green, Nelson Chao, Saurabh Chhabra, Kelly Corbet, Cristina Gasparetto, Ari Horwitz, Zhiguo Li, Jagadish Kummetha Venkata, Gwynn Long, Alice Mims, David Rizzieri, Stefanie Sarantopoulos, Robert Stuart, Anthony D. Sung, Keith M. Sullivan, Luciano Costa, Mitchell Horwitz%u2020 and Yubin Kang View

Clinical and Immunomodulatiory Outcomes of Microtransplantation for AMLDavid A. Rizzieri, MD, Arati V. Rao, MD, Anne Beaven, MD, Danielle Brander, MD, Carlos DeCastro, MD, Louis Diehl, MD, Thomas W. LeBlanc, MD, Gwynn D. Long, MD, Matthew McKinney, MD, Bonnie Toaso, Nelson J. Chao, MD, MBA, Anthony D. Sung, MD View

The Implementation of a Palliative Care Nurse Practitioner-Led Outpatient Clinic within a Large Ambulatory Hematopoietic Stem Cell Transplant ProgramKrista Rowe, RN, MSN, AOCNS, Melanie Reynolds, RN, Megan Weese, BSN, Jennifer Frith, RN, BSN, OCN, Mark Waters, MPH, ANP-BC, ACHPN, Nelson J. Chao, MD, MBA View

Efficacy of Autologous Stem Cell Transplantation in Older Multiple Myeloma PatientsLi-Wen Huang, MD, Wendi Bacon, BS, Constance Cirrincione, MS, Bercedis Peterson, PhD, Gwynn D. Long, MD, David A. Rizzieri, MD, Mitchell E. Horwitz, MD, Keith Sullivan, MD, Kelly Corbet, BS, Nelson J. Chao, MD, MBA, Cristina Gasparetto, MD, Sascha Tuchman, MD View

The Diagnostic Yield of Site and Symptom-Based Biopsies for Acute Gastrointestinal Graft-Versus-Host Disease: A 5-Year Retrospective ReviewDaniel Wild, Anthony D. Sung, Diana Cardona, Constance Cirricione, Keith Sullivan, Claire Detweiler, Michael Shealy, Bryan Balmadrid, Krista L. Rowes, Nelson Chao, Sadhna Piryani, Hossein Mehdikhani Karimabad, Paul Martin, Martin Poleski View

Growth Factor Receptor-Bound Protein 10 (Grb10) Regulates Hematopoietic Stem Cell (HSC) Self-Renewal and Regeneration Via Control of mTOR SignalingJohn P. Chute, M.D., Xiao Yan, Heather A. Himburg, PhD, Phuong L. Doan, MD, Mamle Quarmyne, Evelyn Tran, Nelson J. Chao, MD, MBA, Liman Zhao643 View

Universal Mask Usage for Reduction of Respiratory Viral Infections After Stem Cell Transplant: A Prospective Trial.Sung AD, Sung JA, Thomas S, Hyslop T, Gasparetto C, Long G, Rizzieri D, Sullivan KM, Corbet K, Broadwater G, Chao NJ, Horwitz ME.Clin Infect Dis. 2016 Oct 15;63(8):999-1006. View

Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration.Yan X, Himburg HA, Pohl K, Quarmyne M, Tran E, Zhang Y, Fang T, Kan J, Chao NJ, Zhao L, Doan PL, Chute JP.Cell Rep. 2016 Nov 1;17(6):1584-1594. View

Outcomes of Maintenance Therapy with Bortezomib Post-Autologous Stem Cell Transplantation for Patients with Multiple Myeloma.Sivaraj D, Green MM, Li Z, Sung AD, Sarantopoulos S, Kang Y, Long GD, Horwitz ME, Lopez RD, Sullivan KM, Rizzieri DA, Chao NJ, Gasparetto C.Biol Blood Marrow Transplant. 2016 Nov 14. pii: S1083-8791(16)30488-8. [Epub ahead of print] View