The primary objective of my basic research is to elucidate the roles of fetal and placental hormones in the regulation of maternal metabolism and fetal growth. My work has focused on the lactogenic hormones produced by the pituitary gland and placenta. In recent studies we have explored the molecular mechanisms by which prolactin and placental lactogen regulate pancreatic insulin production and control lipid metabolism during pregnancy and postnatal life.
I also have a clinical research interest in the pathogenesis and treatment of obesity and hyperlipidemia and the prevention of type 2 diabetes. Recent studies show that the drug metformin reduces fat stores and blood glucose and insulin levels in obese adolescents and may reduce the risk of progression to diabetes in selected patients. Finally, we are exploring the clinical course of diabetic children with celiac disease, an common intestinal disorder that affects nutrient absorption.
Owino, V, Ahmed, T, Freemark, M, Kelly, P, Loy, A, Manary, M, and Loechl, C. "Environmental Enteric Dysfunction and Growth Failure/Stunting in Global Child Health." PEDIATRICS 138, no. 6 (December 1, 2016): e20160641-e20160641.
Shashi, V, Pena, LD, Kim, K, Burton, B, Hempel, M, Schoch, K, Walkiewicz, M, McLaughlin, HM, Cho, M, Stong, N, Hickey, SE, Shuss, CM, Freemark, MS, Bellet, JS, Keels, MA, Bonner, MJ, El-Dairi, M, Butler, M, Kranz, PG, Stumpel, CT, Klinkenberg, S, Oberndorff, K, Alawi, M, Santer, R, Petrovski, S, Kuismin, O, Korpi-Heikkilä, S, Pietilainen, O, Aarno, P, Kurki, MI, Hoischen, A, Need, AC, Goldstein, DB, and Kortüm, F. "De Novo Truncating Variants in ASXL2 Are Associated with a Unique and Recognizable Clinical Phenotype." American journal of human genetics 99, no. 4 (October 2016): 991-999.
Irizarry, KA, Miller, M, Freemark, M, and Haqq, AM. "Prader Willi Syndrome." Advances in Pediatrics 63, no. 1 (August 2016): 47-77.
Tamborlane, WV, Haymond, MW, Dunger, D, Shankar, R, Gubitosi-Klug, R, Bethin, K, Karres, J, Tomasi, P, Libman, I, Hale, PH, Portman, R, Klingensmith, G, Reed, M, Blumer, J, and Giacoia, G. "Expanding Treatment Options for Youth With Type 2 Diabetes: Current Problems and Proposed Solutions." Diabetes Care 39, no. 3 (March 2016): 323-329.