My research focuses on the ecology and evolution of infectious diseases. I use a combination of mathematical and statistical approaches to understand the processes driving the disease dynamics of pathogens. My interests include the effect of climate on disease dynamics and the role that immune escape plays in the ecological dynamics of RNA viruses. Current projects focus on influenza, dengue, and norovirus.
Covers the physiology and the ecological and evolutionary dynamics of a suite of infectious diseases. Case studies will include measles, influenza, dengue, cholera, Lyme disease, herpes, tuberculosis, and rabies, among others, with an emphasis on pathogens infecting humans. Topics include: basic immunology, the physiology of different disease processes and transmission, the role of population size on disease transmission, the effects of climate and behavioral changes on disease dynamics, networks of disease spread, spatial spread of disease, evolution of virulence, antigenic evolution, emerging infectious diseases. Koelle and Johnsen.
Was: BIOLOGY 146
|UG Only||SPRING 2013||
MAJOR: Focused Study
Deep Sequencing of Influenza A Virus from a Human Challenge Study Reveals a Selective Bottleneck and Only Limited Intrahost Genetic Diversification., 12, 2016 Sobel Leonard, A; McClain, MT; Smith, GJ; Wentworth, DE; Halpin, RA; Lin, X; Ransier, A; Stockwell, TB; Das, SR; Gilbert, AS; Lambkin-Williams, R; Ginsburg, GS; Woods, CW; Koelle, K, Journal of virology. 90 vol. (24); pp. 11247-11258
Drivers of Inter-individual Variation in Dengue Viral Load Dynamics, 11, 2016 Ben-Shachar, R; Schmidler, S; Koelle, K, PLoS computational biology. 12 vol. (11); pp. e1005194-e1005194
The Long-Term Safety, Public Health Impact, and Cost-Effectiveness of Routine Vaccination with a Recombinant, Live-Attenuated Dengue Vaccine (Dengvaxia): A Model Comparison Study, 11, 2016 Flasche, S; Jit, M; Rodríguez-Barraquer, I; Coudeville, L; Recker, M; Koelle, K; Milne, G; Hladish, TJ; Perkins, TA; Cummings, DAT; Dorigatti, I; Laydon, DJ; España, G; Kelso, J; Longini, I; Lourenco, J; Pearson, CAB; Reiner, RC; Mier-y-Terán-Romero, L; Vannice, K; Ferguson, N, PLoS medicine. 13 vol. (11); pp. e1002181-e1002181
Koelle, K. and D.A. Rasmussen (2015). The effects of a deleterious mutation load on patterns of influenza A/H3N2’s antigenic evolution in humans. eLife. doi: 10.7554/eLife.07361
Ben-Shachar, R. and K. Koelle (2015). Minimal within-host dengue models highlight the specific roles of the immune response in primary and secondary dengue infections. Journal of the Royal Society, Interface. 12 (103), p. 20140886. doi: 10.1098/rsif.2014.0886
Koelle, K. and D.A. Rasmussen (2014). Influenza: prediction is worth a shot. Nature. 507 (7490), pp. 47-48.doi:10.1038/nature13054
Rasmussen, D.A., Volz, E., and K. Koelle (2014). Phylodynamic inference for structured epidemiological models. PLoS Computational Biology. 10(4), p. e1003570.doi:10.1371/journal.pcbi.1003570