My research relates to clinical practice improvement - from the development of clinical policies to their implementation in real world clinical settings. Most recently my major content focus has been cerebrovascular disease. Other major clinical areas in which I work include the range of disabling neurological conditions, cardiovascular disease, and cancer prevention.
Notable features of my work are: (1) reliance on analytic strategies such as meta-analysis, simulation, decision analysis and cost-effectiveness analysis; (2) a balancing of methodological rigor the needs of medical professionals; and (3) dependence on interdisciplinary groups of experts.
This approach is best illustrated by the Stroke Prevention Patient Outcome Research Team (PORT), for which I served as principal investigator. Funded by the AHCPR, the PORT involved 35 investigators at 13 institutions. The Stroke PORT has been highly productive and has led to a stroke prevention project funded as a public/private partnership by the AHCPR and DuPont Pharma, the Managing Anticoagulation Services Trial (MAST). MAST is a practice improvement trial in 6 managed care organizations, focussing on optimizing anticoagulation for individuals with atrial fibrillation.
I serve as consultant in the general area of analytic strategies for clinical policy development, as well as for specific projects related to stroke (e.g., acute stroke treatment, management of atrial fibrillation, and use of carotid endarterectomy.) I have worked with AHCPR (now AHRQ), ACP, AHA, AAN, Robert Wood Johnson Foundation, NSA, WHO, and several pharmaceutical companies.
Tian, Y, Hassmiller Lich, K, Osgood, ND, Eom, K, and Matchar, DB. "Linked Sensitivity Analysis, Calibration, and Uncertainty Analysis Using a System Dynamics Model for Stroke Comparative Effectiveness Research." Medical decision making : an international journal of the Society for Medical Decision Making 36, no. 8 (November 2016): 1043-1057.PMID: 27091379
Bee, YM, Batcagan-Abueg, AP, Chei, CL, Do, YK, Haaland, B, Goh, SY, Lee, PC, Chiam, PP, Ho, ET, and Matchar, DB. "A Smartphone Application to Deliver a Treat-to-Target Insulin Titration Algorithm in Insulin-Naive Patients With Type 2 Diabetes: A Pilot Randomized Controlled Trial." Diabetes care 39, no. 10 (October 2016): e174-e176. (Letter) PMID: 27506223
Matchar, DB, Chei, CL, Yin, ZX, Koh, V, Chakraborty, B, Shi, XM, and Zeng, Y. "Vitamin D Levels and the Risk of Cognitive Decline in Chinese Elderly People: the Chinese Longitudinal Healthy Longevity Survey." The journals of gerontology. Series A, Biological sciences and medical sciences 71, no. 10 (October 2016): 1363-1368. PMID: 27412894
Phibbs, CS, Love, SR, Jacobson, AK, Edson, R, Su, P, Uyeda, L, and Matchar, DB. "At-Home Versus In-Clinic INR Monitoring: A Cost-Utility Analysis from The Home INR Study (THINRS)." Journal of general internal medicine 31, no. 9 (September 2016): 1061-1067. PMID: 27234663
Chan, A, Malhotra, R, Matchar, DB, Ma, S, and Saito, Y. "Gender, educational and ethnic differences in active life expectancy among older Singaporeans." Geriatrics & gerontology international 16, no. 4 (April 2016): 466-473. PMID: 25868426
Ansah, JP, Matchar, DB, Malhotra, R, Love, SR, Liu, C, and Do, Y. "Projecting the effects of long-term care policy on the labor market participation of primary informal family caregivers of elderly with disability: insights from a dynamic simulation model." BMC geriatrics 16 (March 23, 2016): 69. PMID: 27007720
Lv, YB, Yin, ZX, Chei, CL, Brasher, MS, Zhang, J, Kraus, VB, Qian, F, Shi, X, Matchar, DB, and Zeng, Y. "Serum cholesterol levels within the high normal range are associated with better cognitive performance among Chinese elderly." Journal of Nutrition, Health and Aging 20, no. 3 (March 1, 2016): 280-287.
Liu, C, Eom, K, Matchar, DB, Chong, WF, and Chan, AW. "Community-Based Long-Term Care Services: If We Build It, Will They Come?." Journal of aging and health 28, no. 2 (March 2016): 307-323.PMID: 26129700
Lv, YB, Yin, ZX, Chei, CL, Brasher, MS, Zhang, J, Kraus, VB, Qian, F, Shi, XM, Matchar, DB, and Zeng, Y. "Serum Cholesterol Levels within the High Normal Range Are Associated with Better Cognitive Performance among Chinese Elderly." The journal of nutrition, health & aging 20, no. 3 (March 2016): 280-287. PMID: 26892577
Malhotra, R, Chei, CL, Menon, E, Chow, WL, Quah, S, Chan, A, and Matchar, DB. "Short-Term Trajectories of Depressive Symptoms in Stroke Survivors and Their Family Caregivers." Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 25, no. 1 (January 2016): 172-181. PMID: 26476585
Rose, AJ, Phibbs, CS, Uyeda, L, Su, P, Edson, R, Shih, MC, Jacobson, A, and Matchar, DB. "Does distance modify the effect of self-testing in oral anticoagulation?." The American journal of managed care 22, no. 1 (January 2016): 65-71. PMID: 26799126