Dr. Permar's work focuses on maternal correlates of immune protection against vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS, Simian Immunodeficiency Virus (SIV) infection of rhesus monkeys, to characterize the virus-specific immune responses and virus evolution in breast milk. Furthermore, the Permar lab is characterizing HIV/SIV vaccine-elicited immune responses in breast milk of vaccinated rhesus monkeys, as a platform for developing a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Finally, Dr. Permar has established studies of maternal cytomegalovirus-specific immune responses that may protect against symptomatic congenital cytomegalovirus and postnatal transmission in preterm infants.
Mwila, K, Chilengi, R, Simuyandi, M, Permar, SR, and Becker-Dreps, S. "Contribution of Maternal Immunity to Decreased Rotavirus Vaccine Performance in Low- and Middle-Income Countries." Clinical and vaccine immunology : CVI 24, no. 1 (January 2017). (Review)
Nguyen, QN, Himes, JE, Martinez, DR, and Permar, SR. "The Impact of the Gut Microbiota on Humoral Immunity to Pathogens and Vaccination in Early Infancy." PLoS pathogens 12, no. 12 (December 22, 2016): e1005997.
Aliota, MT, Dudley, DM, Newman, CM, Mohr, EL, Gellerup, DD, Breitbach, ME, Buechler, CR, Rasheed, MN, Mohns, MS, Weiler, AM, Barry, GL, Weisgrau, KL, Eudailey, JA, Rakasz, EG, Vosler, LJ, Post, J, Capuano, S, Golos, TG, Permar, SR, Osorio, JE, Friedrich, TC, O'Connor, SL, and O'Connor, DH. "Heterologous Protection against Asian Zika Virus Challenge in Rhesus Macaques." PLoS neglected tropical diseases 10, no. 12 (December 2, 2016): e0005168.
Bialas, KM, Westreich, D, Cisneros de la Rosa, E, Nelson, CS, Kauvar, LM, Fu, TM, and Permar, SR. "Maternal Antibody Responses and Nonprimary Congenital Cytomegalovirus Infection of HIV-1-Exposed Infants." The Journal of infectious diseases 214, no. 12 (December 2016): 1916-1923.
Himes, JE, Ho, C, Nguyen, QN, Amos, JD, Xu, H, Chan, C, Chow, SC, Ochsenbauer, C, Kaidarova, Z, Keating, SM, Fouda, GG, and Permar, SR. "Characterization of Simian Immunodeficiency Virus Variants Anatomically Compartmentalized in Plasma and Milk in Chronically Infected African Green Monkeys." Journal of virology 90, no. 19 (October 2016): 8795-8808.
Martinez, DR, McGuire, E, Permar, SR, and Fouda, GG. "Variable IgG Transplacental Transfer in the Setting of Maternal HIV Infection." October 2016.
Zhang, R, Martinez, DR, Nguyen, QN, Pollara, J, Arifin, T, Stolarchuk, C, Foulger, A, Amos, JD, Parks, R, Himes, JE, Wang, M, Edwards, RW, Trama, AM, Vandergrift, N, Colvin, L, Dewar, K, Juretic, N, Wasserscheid, J, Ferrari, G, Liao, HX, and Permar, SR. "Envelope-specific B-cell populations in African green monkeys chronically infected with simian immunodeficiency virus." Nature communications 7 (July 6, 2016): 12131-.
Mukhopadhyay, S, Meyer, SA, Permar, SR, and Puopolo, KM. "Symptomatic Postnatal Cytomegalovirus Testing among Very Low-Birth-Weight Infants: Indications and Outcomes." American journal of perinatology 33, no. 9 (July 2016): 894-902.
Dudley, DM, Aliota, MT, Mohr, EL, Weiler, AM, Lehrer-Brey, G, Weisgrau, KL, Mohns, MS, Breitbach, ME, Rasheed, MN, Newman, CM, Gellerup, DD, Moncla, LH, Post, J, Schultz-Darken, N, Schotzko, ML, Hayes, JM, Eudailey, JA, Moody, MA, Permar, SR, O'Connor, SL, Rakasz, EG, Simmons, HA, Capuano, S, Golos, TG, Osorio, JE, Friedrich, TC, and O'Connor, DH. "A rhesus macaque model of Asian-lineage Zika virus infection." Nature communications 7 (June 28, 2016): 12204.
Nelson, CS, Pollara, J, Kunz, EL, Jeffries, TL, Duffy, R, Beck, C, Stamper, L, Wang, M, Shen, X, Pickup, DJ, Staats, HF, Hudgens, MG, Kepler, TB, Montefiori, DC, Moody, MA, Tomaras, GD, Liao, HX, Haynes, BF, Ferrari, G, Fouda, GG, and Permar, SR. "Combined HIV-1 Envelope Systemic and Mucosal Immunization of Lactating Rhesus Monkeys Induces a Robust Immunoglobulin A Isotype B Cell Response in Breast Milk." Journal of virology 90, no. 10 (May 2016): 4951-4965.
Becker-Dreps S, Choi WS, Stamper L, Vilchez S, Velasquez DE, Moon SS, Hudgens MG, Jiang B, Permar SR. Innate Immune Factors in Mothers' Breast Milk and Their Lack of Association With Rotavirus Vaccine Immunogenicity in Nicaraguan Infants. J Pediatric Infect Dis Soc. 2015 Nov 17. pii: piv076. PMID: 26582774
Lantos, Paul, Permar SR, Hoffman, Kate, Swamy, Geeta. The excess burden of cytomegalovirus in African-American communities: a geospatial analysis. Open Forum Infect Dis. Online November 19, 2015.
Kimberlin, DW. Sequale following Postnatally Acquired Cytomegalovirus Infection in Very Low-birth-Weight Neonates. JAMA Pediatr. Published online December 7, 2015. PMID: 26642119
Kelly MS, Benjamin DK, Puopolo KM, Laughon MM, Clark RH, Mukhopadhyay S, Benjamin Jr DK, Smith PB, Permar SR. Postnatal cytomegalovirus infection and the risk of bronchopulmonary dysplasia. JAMA Pediatr. 2015;169(12):e153785; PMID: 26642118
Bialas, K.M.; Tanaka, T; Tran, D; Varner, V; Cisneros De La Rosa, E; Chiuppesi, F; Wussow, F; Kattenhorn, L; Macri, S; Kunz, E; Estroff, J; Kirchherr, J; Yue, Y ; Fan, Q; Lauck, M; O'Connor, DH; Hall, A; Xavier, A; Diamond, DJ; Barry, PA; Kaur, A; Permar, SR. Maternal CD4 T cells protect against severe congenital cytomegalovirus disease in a novel nonhuman primate model of placental cytomegalovirus transmission. Proceedings of the National Academy of Sciences, 2015 Nov 3;112(44):13645-50; PMID: 26483473
Wahl, A, Baker, C, Spagnuolo, RA, Stamper, L, Fouda, G, Permar, SR, Hinde, K, Kuhn, L, Bode, L, Aldrovandi, G, and Garcia, V.J. Breast milk of HIV-positive mothers has potent and species-specific in vivo HIV inhibitory activity. Journal of Virology, 2015 Nov 1;89(21):10868-78; PMID: 26292320
Jeffries T.J, Sacha, C.R., Pollara, J, Himes, J, Jaeger, FJ, Dennison, S.M., McGuire, E, Kunz, E, Eudailey, J, Trama, AM, LaBranche, C, Fouda, GG, Wiehe, K, Montefiori, D, Haynes, BF, Liao, HX, Ferrari, G, Alam, SM, Moody, MA and Permar, S.R. The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells. Mucosal Immunology, 2015 Aug 5; PMID: 26242599
Pollara, J, McGuire, E, Fouda, G, Rountree, W, Eudailey, J, Overman, G.R., Seaton,K, Deal, A, Edwards, R, Tegha G, Kamwendo, D, Kumwenda, J, Nelson, J, Liao, H.X., Brinkley, C, Denny, T.N., Ochsenbauer, C, Ellington, S, King, C, Jamieson, D, van der Horst, C, Kourtis, A, Tomaras, G, Ferrari, G, and Permar, S.R. Association of HIV-1 Envelope-Specific Breast Milk IgA Responses with Reduced Risk of Postnatal Mother-to-Child Transmission of HIV-1. Journal of Virology, Oct 1;89(19):9952-61; PMID: 26202232
Amos JD, Himes JE, Armand L, Gurley TC, Martinez DR, Colvin, L, Beck K, Overman RG, Liao HX, Moody, MA, Permar SR. Rapid development of gp120 focused, neutralizing B cell responses during acute simian immunodeficiency virus infection of African green monkeys. J Virol. 2015 Sep 15;89(18):9485-98; PMID: 26157116
Permar SR, Fong, Y, Vandergrift N, Fouda GG, Gilbert P, Parks R, Jaeger FH, Pollara J, Martelli A, Liebl BE, Lloyd K, Yates NL, Overman RG, Shen X, Whitaker K, Chen H, Pritchett J, Solomon E, Friberg E, Marshall DJ, Whitesides JF, Gurley Tc, Von Holle T, Martinez Dr, Cai F, Kumar A, Xia SM, Lu X, Louzao R, Wilkes S, Datta S, Sarzotti-Kelsoe M, Liao HX, Ferrari G, Alam SM, Montefiori DC, Denny TN, Moody MA, Tomaras GD, Gao F, Haynes BF. Maternal HIV-1 envelope-specific antibody responses and reduced risk of perinatal transmission. J Clin Invest 2015 June; PMID: 26053661
Shen X, Duffy R, Howington R, Cope A, Sadagopal S, Park H, Pal R, Kwa S, Ding S, Yang OO, Fouda GG, Le Grand R, Bolton D, Esteban M, Phogat S, Roederer M, Amara R, Picker LJ, Seder Ra, McElrath MJ, Barnett S, Permar SR, Shattock R, DeVico AL, Felber BK, Pavlakis GN, Pantaleo G, Korber BT, Montefiori DC, Tomaras, GD. Vaccine Induced Epitope Specific Antibodies to SIVmac239 Envelope Are Distinct from Those Induced to the HIV-1 Envelope in Non-Human Primates. Journal of Virology 2015 May; PMID: 26018159
Richard J, Veillette M, Brassard N, Iyer SS, Roger M, Martin L, Pazgier M, Schon A, Freire E, Routy JP, Smith Ab 3rd, Park J, Jones DM, Courter JR, Melillo BN, Kaufman De, Hahn, BH, Permar SR, Haynes BF, Madani N, Sodroski JG, Finzi A. CD4 mimetics sensitize HIV-1-infected cells to ADCC. Proc Natl Acad Sci USA 2015 May; 112: E2687-94. PMID: 25941367
Fouda, G.G.; Moody, M.A.; Permar, SR. Antibodies for Prevention of mother to child transmission of HIV-1. Current Opinions in HIV and AIDS. 2015 May; 10:177-82. PMID: 25700205
Fong Y, Di C, Permar SR. Change Point Testing in Logistic Regression Models with Interaction Term. Statistics in Medicine. Stat Med. 2015 Apr 30;34(9):1483-94.
Bialas, K, Swamy, GK, Permar, SR. Perinatal cytomegalovirus and varicella zoster virus infections: epidemiology, prevention, and treatment. Clinics in Perinatology. 2015 Mar; 42:61-75 PMID: 25677997
Sacha, C.R, Vandergrift, N, Jeffries, TL., McGuire, E, Fouda, G.G., Liebl, BE, Marshall, DJ, Gurley, TC, Stiegel, LC, Whitesides, JF, Friedman, J, Badiabo, A, Foulger, A, Yates, NL, Tomaras, GD, Kepler, TB, Liao, HX, Haynes, BF, Moody, MA, and Permar, SR. Restricted isotype, distinct variable gene usage, and high rate of gp120-specificity of HIV-1 Envelope-specific B cells in colostrum compared to those in blood of HIV-1-infected, lactating African women. Mucosal Immunol. 2015 Mar 8: 316-26. PMID: 25100291
Fouda, GG, Cunningham, CK, McFarland, EJ, Borkowsky, W, Muresan, P, Pollara, J, Song, LY, Liebl, BE, Whitaker, K, Shen, X, Vandergrift, N, Overman, RG, Yates, NL, Moody, MA, Fry, C, Kim, JH, Michael, NL, Robb, M, Pitisuttihum, P, Kaewkungwal, J, Nitayaphan, S, Rerks-Ngarm, S, Liao, HX, Haynes, B , Montefiori, DC, Ferrari, G, Tomaras, GD and Permar, SR. Infant HIV-1 gp120 vaccination elicits robust and durable anti-V1V2 IgG responses and only rare Envelope-specific IgA responses. Journal of Infectious Diseases. 2015 Feb 15; 211:508-517 PMID: 25170104