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Faculty

Wendy Prudhomme - O'Meara

Associate Professor, Medicine and Global Health
School of Medicine
Medicine: Infectious Diseases

Eldoret, Kenya
(919) 681-7711
wendy.omeara@duke.edu

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Wendy Prudhomme - O'Meara

Summary

Dr. O'Meara has been actively working and publishing in the field of malaria diagnosis, treatment, and drug resistance since 2004. She is an Associate Professor at Duke University Medical School in the Division of Infectious Diseases, visiting professor at Moi University, and the Co-Field Director of Research for AMPATH. She has been based full-time in Kenya since 2007.

Dr. O'Meara's team is interested in improving rational drug use for suspected malaria fevers through expanding the use of diagnostic tools in the community and in health facilities. As many as 90% of fevers that seek treatment in the formal sector receive antimalarials, and it is estimated that only 20% of those buying antimalarials over-the-counter in the retail sector actually have malaria. Such overuse poses a significant threat to the continued efficacy of first-line antimalarials. Dr. O'Meara has conducted several randomized controlled trials in western Kenya to test interventions designed to improve the use of information from malaria diagnostic testing in order to target antimalarials to those with confirmed infection. In 2005, she helped to establish the Malaria Diagnostic Centre of Excellence in Kisumu, Kenya.

Recently, she concluded a case-controlled study with colleagues at Moi University that identified the major determinants of insecticide treated bednet failure in western Kenya. Among other results, the study showed that asymptomatically infected household members may be a risk factor for children living in the same household. Current work is extending this observation by leveraging variability in key parasite genes to describe the spatial mixing of malaria infections and track generations of infections from humans to mosquitoes (collaboration with Steve Taylor's lab).

Dr. O'Meara has experience in marrying innovative spatial techniques with epidemiologic outcomes. Recent work includes an analysis of health systems factors that contribute to early childhood mortality in sub-Saharan Africa.

Locations

Teaching

Title Number Level Semester Requirements Fulfilled
Infectious Disease Epidemiology in Global Settings-- Surveillance, Prevention, and Control

Focus on communicable diseases in global settings, spanning individual level of diagnosis & treatment of infectious cases to population-level disease surveillance, prevention & control. Examines relationships between infectious disease & environmental health, including veterinary health. Expands upon topics introduced in MSc-GH core graduate coursework to build towards integrated understanding of infectious disease epidemiology. Three modules: 1) Foundations in Infectious Disease Epidemiology, 2) Disease Surveillance & Prevention, 3) Disease Treatment & Control. Course taught exclusively on-line. Open to graduate students at Duke and DKU only.

Course Notes:
GLHLTH 777
Was: GLHLTH 5839
GRAD Only SPRING 2018 MSC: Elective
Infectious Disease Epidemiology in Global Settings-- Surveillance, Prevention, and Control

Focus on communicable diseases in global settings, spanning individual level of diagnosis & treatment of infectious cases to population-level disease surveillance, prevention & control. Examines relationships between infectious disease & environmental health, including veterinary health. Expands upon topics introduced in MSc-GH core graduate coursework to build towards integrated understanding of infectious disease epidemiology. Three modules: 1) Foundations in Infectious Disease Epidemiology, 2) Disease Surveillance & Prevention, 3) Disease Treatment & Control. Course taught exclusively on-line. Open to graduate students at Duke and DKU only.

Course Notes:
GLHLTH 777
Was: GLHLTH 5839
GRAD Only SPRING 2017 MSC: Elective

Projects

Recent Publications

"Overlap Extension Barcoding for the Next Generation Sequencing and Genotyping of Plasmodium Falciparum in Individual Patients in Western Kenya" Brandt Levitt, Andrew Obala, Scott Langdon, David Corcoran, Wendy Prudhomme-O'Meara, Steve TaylorScientific Reports (IN PRESS)

I.Chen, S. Clarke, R. Gosling, B. Hamainza, G. Killeen, A. Magill, W. O'Meara, R. Price, E. Riley, "Asymptomatic malaria: a chronic and debilitating infection that should be treated" PLoS Medicine 13(1):e1001942 (2016)

S. Ndege, S. Washington, A. Kaaria, W. Prudhomme O'Meara, E. Were, M. Nyambura, A. Keter, J. Wachira, P. Braitstein "HIV prevalence and antenatal care attendance among pregnant women in a large home-based HIV counseling and testing program in western Kenya" PLoS One 11(1):e0144618 (2016)

A. Maina, C. Farris, A. Odhiambo, J. Jiang, J. Laktabai, J. Armstrong, T. Holland, A. Richards, W.P. O'Meara "Q-fever, scrub typhus, and rickettsial diseases as common causes of undifferentiated fevers among pediatric patients in western Kenya" Emerging Infectious Diseases 22(5):883-6 (2016)

W. Prudhomme O'Meara, M. Mohanan, J. Laktabai, A. Lesser, A. Platt, E. Maffioli, E.L. Turner, D. Menya, "Assessing the independent and combined effects of subsidies for antimalarials and rapid diagnostic testing on fever management decisions in the retail sector: results from a factorial randomised trial in western Kenya" BMJ Global Health 2016;1:e000101

R.H. Lumsden, C. Akwanalo, S. Chepkwony, A. Kithei, V. Omollo, T.L. Holland, G.S. Bloomfield, W.P. O'Meara "Clinical and geographic patterns of rheumatic heart disease in outpatients attending cardiology clinic in western Kenya" International Journal of Cardiology 223:228-235 PMID: 27541662 (2016)

W. Oyibo, N. Ezeigwe, G. Ntadom, O. Oladosu, K. Rainwater, W. O'Meara, E. Okpokoro, and W. Brieger "A Multicenter Pivotal Clinical Trial of a Urine Malaria Test (UMT) for the Rapid Diagnosis of Plasmodium falciparum Malaria", Journal of Clinical Microbiology 2016 IN PRESS

J.N. Mangeni, D. Menya, A.A. Obala, A. Platt, W. P. O'Meara, "Development and piloting of an evidence-based rapid assessment tool for malaria prevention", Malaria Journal IN PRESS 2016

I. Nkumama, W.P.O'Meara, F.H.A. Osier, "Changes in malaria epidemiology in Africa and new challenges for elimination" Trends in Parasitology IN PRESS 2016

W.P. O'Meara, J. Mott, J. Laktabai, K. Wamburu, B. Fields, J. Armstrong, S. Taylor, C. MacIntyre, R. Sen, D. Menya, W. Pan, B. Nicholson, C. Woods, T. Holland "Etiology of pediatric fever in Western Kenya: A case-control study of falciparum malaria, respiratory viruses, and streptococcal pharyngitis" American Journal of Tropical Medicine and Hygiene,92(5):1030-7 (2015)

A. Wesolowski, W. Prudhomme O'Meara, A.Tatem, S. Ndege, N. Eagle, C. Buckee "Quantifying the impact of accessibility on preventative healthcare in Sub-Saharan Africa", Epidemiology, 26:223—228 (2015)

A. Wesolowski, W. Prudhomme O'Meara, N. Eagle, A.Tatem, C. Buckee "Evaluating spatial interaction models for regional mobility in Sub-Saharan Africa", PLoS Computational Biology 11(7): e1004267 (2015)

A. A. Obala, J. Mangeni, A. Platt, D. Aswa, L. Abel, J. Namae, W. Prudhomme O'Meara "What Is Threatening the Effectiveness of Insecticide-Treated Bednets? A Case-Control Study of Environmental, Behavioral, and Physical Factors Associated with Prevention Failure", PLoS One 2015 10(7):e0132778

D. Menya, A. Platt, I. Manji, E. Sang, R, Wafula, J. Ren, O. Cheruiyot, J. Armstrong, B. Neelon, W. Prudhomme O'Meara, "Using pay for performance incentives (P4P) to improve management of suspected malaria fevers in rural Kenya: a cluster randomized controlled trial" BMC Medicine 13:268 (2015)

R. Wafula, E. Sang, O. Cheruiyot, A. Aboto, D. Menya, W.P. O'Meara "High sensitivity and specificity of clinical microscopy in rural health facilities in western Kenya under an EQA program" American Journal of Tropical Medicine and Hygiene 91(3):481-5 (2014)

E. Mwaliko, R. Downing, W.P.O'Meara, D. Chelegat, A. Obala, T. Downing, C. Simiyu, D. Odhiambo, P. Ayuo, D.Menya, B. Khwa-Otsyula "'Not too far to walk': the influence of distance on place of delivery in a western Kenya health demographic surveillance system" BMC Health Services Research IN PRESS (2014)

W.P. O'Meara, S. Karuru, L.E. Fazen, J. Koech, B. Kizito, C. Tarus, D. Menya "Heterogeneity in health seeking behaviour for treatment, prevention and urgent care in four districts in western Kenya" Public Health 128:993-1008 (2014)

W. P. O'Meara, A. Platt, V. Naanyu, D. Cole, S. Ndege, "Spatial autocorrelation in uptake of antenatal care and relationship to individual, household and village-level factors: results from a community-based survey of pregnant women in six districts in western Kenya"International Journal of Health Geographics 12:55 (2013)

H. Thirumurthy, A. Obala, B. Khwa-Otsyula, W.P. O'Meara; The effect of price, competition, and demand factors on private sector antimalarial stocking and sales in western Kenya: considerations for the AMFm subsidy; Malaria Journal 2013, 12:186

A. Rusk, C. Goodman, V. Naanyu, B. Koech, A. Obala, W.P. O'Meara "Expanding access to malaria diagnosis through retail shops in western Kenya: What do shop workers think?" Malaria Research and Treatment. Volume 2013 (2013), Article ID 398143

Diana Menya, John Logedi, Imran Manji, Janice Armstrong, Brian Neelon and Wendy Prudhomme O'Meara* An innovative pay-for-performance (P4P) strategy for improving malaria management in rural Kenya: protocol for a cluster randomized controlled trial Implementation Science 8:48 (2013)

alerian Lugwana Kiggundu, MBChB, MPH; Wendy P O' Meara; Richard Musoke; Fred K. Nalugoda; Godfrey Kigozi; Enos Baghendaghe; Tom Lutalo; Marion K. Achienge; Steven J. Reynolds; Fred Makumbi; David Serwadda; Ronald H. Gray; Wools-Kaloustian K. Kara; High prevalence of malaria parasitemia and anemia among hospitalized children in Rakai, UgandaPLoS ONE 8(12): e82455

Prudhomme O'Meara Wendy, Platt Alyssa, Naanyu Violet, Cole Donald, Ndege SamsonSpatial autocorrelation in uptake of antenatal care and relationship to individual, household and village-level factors: results from a community-based survey of pregnant women in six districts in western KenyaInternational Journal of Health Geographics.2013, 12:55.

A. Rusk, N. Smith, D. Menya, A. Obala, C. Simiyu, B. Khwa-Otsyla, W.P.O'Meara Does anti-malarial drug knowledge predict anti-malarial dispensing practice in drug outlets? A survey of medicine retailers in western Kenya Malaria Journal 2012

E. Billig, W.P. O'Meara, E.M. Riley and F.E. McKenzie Developmental allometry and paediatric malaria Malaria Journal 2012, 11:64

N. Smith, A. Obala, C. Simiyu, D. Menya, B. Khwa-Otsyula, W.P. O'Meara "Accessibility, availability and affordability of anti-malarials in a rural district in Kenya after implementation of a national subsidy scheme" Malaria Journal 10:316 (2011)

W.P. O'Meara, N. Smith, E. Ekal, D. Cole, S. Ndege, "Spatial distribution of bednet coverage under routine distribution through the public health sector in a rural district in Kenya" PLoS One 6(10) (2011).