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Svati Shah

Associate Professor, Medicine, Nursing and Global Health
School of Medicine
Medicine: Cardiology

(919) 684-1808

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Svati Shah


Svati H. Shah, MD, MHS, is an Associate Professor of Medicine in the Division of Cardiology, Department of Medicine. She is a board eligible cardiologist and her clinical interests are in genetics, echocardiography, and preventive cardiology. Her research focuses on genetic epidemiology and gene-environment interactions in complex cardiovascular diseases, including dyslipidemia, premature coronary artery disease, aortic stenosis, and peripheral vascular disease. She is also interested in genomic medicine and personalized patient care and has started a complex cardiovascular disease genetics clinic at Duke University Medical Center.



Recent Publications

Voora, D, Coles, A, Lee, KL, Hoffmann, U, Wingrove, JA, Rhees, B, Huang, L, Daniels, SE, Monane, M, Rosenberg, S, Shah, SH, Kraus, WE, Ginsburg, GS, and Douglas, PS. "An age- and sex-specific gene expression score is associated with revascularization and coronary artery disease: Insights from the Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial (Accepted)." American Heart Journal 184 (February 2017): 133-140.

Wang, H, Pun, PH, Kwee, L, Craig, D, Haynes, C, Chryst-Ladd, M, Svetkey, LP, Patel, UD, Hauser, ER, Pollak, MR, Kraus, WE, and Shah, SH. "Apolipoprotein L1 Genetic Variants Are Associated with Chronic Kidney Disease but Not with Cardiovascular Disease in a Population Referred for Cardiac Catheterization." Cardiorenal Medicine (2017): 96-103.

McGarrah, RW, Kelly, JP, Craig, DM, Haynes, C, Jessee, RC, Huffman, KM, Kraus, WE, and Shah, SH. "A Novel Protein Glycan-Derived Inflammation Biomarker Independently Predicts Cardiovascular Disease and Modifies the Association of HDL Subclasses with Mortality." Clinical chemistry 63, no. 1 (January 2017): 288-296.PMID: 27811210

Breitner, S, Schneider, A, Devlin, RB, Ward-Caviness, CK, Diaz-Sanchez, D, Neas, LM, Cascio, WE, Peters, A, Hauser, ER, Shah, SH, and Kraus, WE. "Associations among plasma metabolite levels and short-term exposure to PM2.5 and ozone in a cardiac catheterization cohort." Environment international 97 (December 2016): 76-84. PMID: 27792908

Hampel, R, Breitner, S, Kraus, WE, Hauser, E, Shah, S, Ward-Caviness, CK, Devlin, R, Diaz-Sanchez, D, Neas, L, Cascio, W, Peters, A, and Schneider, A. "Short-term effects of air temperature on plasma metabolite concentrations in patients undergoing cardiac catheterization." Environmental research 151 (November 2016): 224-232. PMID: 27500855

Loley, C, Alver, M, Assimes, TL, Bjonnes, A, Goel, A, Gustafsson, S, Hernesniemi, J, Hopewell, JC, Kanoni, S, Kleber, ME, Lau, KW, Lu, Y, Lyytikäinen, LP, Nelson, CP, Nikpay, M, Qu, L, Salfati, E, Scholz, M, Tukiainen, T, Willenborg, C, Won, HH, Zeng, L, Zhang, W, Anand, SS, Beutner, F, Bottinger, EP, Clarke, R, Dedoussis, G, Do, R, Esko, T, Eskola, M, Farrall, M, Gauguier, D, Giedraitis, V, Granger, CB, Hall, AS, Hamsten, A, Hazen, SL, Huang, J, Kähönen, M, Kyriakou, T, Laaksonen, R, and Lind, L et al. "No Association of Coronary Artery Disease with X-Chromosomal Variants in Comprehensive International Meta-Analysis." Scientific reports 6 (October 12, 2016): 35278-.PMID: 27731410

Mirowsky, JE, Devlin, RB, Diaz-Sanchez, D, Cascio, W, Grabich, SC, Haynes, C, Blach, C, Hauser, ER, Shah, S, Kraus, W, Olden, K, and Neas, L. "A novel approach for measuring residential socioeconomic factors associated with cardiovascular and metabolic health." Journal of exposure science & environmental epidemiology (September 21, 2016). PMID: 27649842

McGarrah, RW, and Shah, SH. "Exomes, Proteins, and Cardiovascular Disease: Making Sense of the Signals." Circulation. Cardiovascular genetics 9, no. 4 (August 2016): 318-319. PMID: 27531916

Samad, Z, Vora, AN, Dunning, A, Schulte, PJ, Shaw, LK, Al-Enezi, F, Ersboll, M, McGarrah, RW, Vavalle, JP, Shah, SH, Kisslo, J, Glower, D, Harrison, JK, and Velazquez, EJ. "Aortic valve surgery and survival in patients with moderate or severe aortic stenosis and left ventricular dysfunction." European heart journal 37, no. 28 (July 2016): 2276-2286. PMID: 26787441

Pagidipati, NJ, Hemal, K, Coles, A, Mark, DB, Dolor, RJ, Pellikka, PA, Hoffmann, U, Litwin, SE, Udelson, J, Daubert, MA, Shah, SH, Martinez, B, Lee, KL, and Douglas, PS. "Sex Differences in Functional and CT Angiography Testing in Patients With Suspected Coronary Artery Disease." Journal of the American College of Cardiology 67, no. 22 (June 2016): 2607-2616. PMID: 27058908

Nioi, P, Sigurdsson, A, Thorleifsson, G, Helgason, H, Agustsdottir, AB, Norddahl, GL, Helgadottir, A, Magnusdottir, A, Jonasdottir, A, Gretarsdottir, S, Jonsdottir, I, Steinthorsdottir, V, Rafnar, T, Swinkels, DW, Galesloot, TE, Grarup, N, Jørgensen, T, Vestergaard, H, Hansen, T, Lauritzen, T, Linneberg, A, Friedrich, N, Krarup, NT, Fenger, M, Abildgaard, U, Hansen, PR, Galløe, AM, Braund, PS, Nelson, CP, Hall, AS, Williams, MJ, van Rij, AM, Jones, GT, Patel, RS, Levey, AI, Hayek, S, and Shah, SH et al. "Variant ASGR1 Associated with a Reduced Risk of Coronary Artery Disease." The New England journal of medicine 374, no. 22 (June 2016): 2131-2141. PMID: 27192541

Hunter, WG, Kelly, JP, McGarrah, RW, Kraus, WE, and Shah, SH. "Metabolic Dysfunction in Heart Failure: Diagnostic, Prognostic, and Pathophysiologic Insights From Metabolomic Profiling." Current heart failure reports 13, no. 3 (June 2016): 119-131. (Review) PMID: 27216948

Sun, H, Olson, KC, Gao, C, Prosdocimo, DA, Zhou, M, Wang, Z, Jeyaraj, D, Youn, JY, Ren, S, Liu, Y, Rau, CD, Shah, S, Ilkayeva, O, Gui, WJ, William, NS, Wynn, RM, Newgard, CB, Cai, H, Xiao, X, Chuang, DT, Schulze, PC, Lynch, C, Jain, MK, and Wang, Y. "Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure." Circulation 133, no. 21 (May 2016): 2038-2049. PMID: 27059949

Hemal, K, Pagidipati, NJ, Coles, A, Dolor, RJ, Mark, DB, Pellikka, PA, Hoffmann, U, Litwin, SE, Daubert, MA, Shah, SH, Ariani, K, Bullock-Palmer, RP, Martinez, B, Lee, KL, and Douglas, PS. "Sex Differences in Demographics, Risk Factors, Presentation, and Noninvasive Testing in Stable Outpatients With Suspected Coronary Artery Disease: Insights From the PROMISE Trial." JACC. Cardiovascular imaging 9, no. 4 (April 2016): 337-346.PMID: 27017234

Guimarães, PO, Sun, JL, Kragholm, K, Shah, SH, Pieper, KS, Kraus, WE, Hauser, ER, Granger, CB, and Newby, LK. "Association of standard clinical and laboratory variables with red blood cell distribution width." American heart journal 174 (April 2016): 22-28. PMID: 26995366

Pereira, NL, Geske, JB, Mayr, M, Shah, SH, and Rihal, CS. "Pharmacogenetics of Clopidogrel: An Unresolved Issue." Circulation. Cardiovascular genetics 9, no. 2 (April 2016): 185-188.PMID: 27094200

de Denus, S, Rouleau, JL, Mann, DL, Huggins, GS, Cappola, TP, Shah, SH, Keleti, J, Zada, YF, Provost, S, Bardhadi, A, Phillips, MS, Normand, V, Mongrain, I, and Dubé, MP. "A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials." March 2016. PMID: 26927285

McGarrah, RW, Craig, DM, Haynes, C, Dowdy, ZE, Shah, SH, and Kraus, WE. "High-density lipoprotein subclass measurements improve mortality risk prediction, discrimination and reclassification in a cardiac catheterization cohort." Atherosclerosis 246 (March 2016): 229-235.PMID: 26803432

Voora, D, and Shah, SH. "Pharmacometabolomics Meets Genetics: A "Natural" Clinical Trial of Statin Effects." Journal of the American College of Cardiology 67, no. 10 (March 2016): 1211-1213.PMID: 26965543

Wolf, MJ, Noeth, D, Rammohan, C, and Shah, SH. "Complexities of Genetic Testing in Familial Dilated Cardiomyopathy." Circulation. Cardiovascular genetics 9, no. 1 (February 2016): 95-99. PMID: 26884609

Ahmad, T, Kelly, JP, McGarrah, RW, Hellkamp, AS, Fiuzat, M, Testani, JM, Wang, TS, Verma, A, Samsky, MD, Donahue, MP, Ilkayeva, OR, Bowles, DE, Patel, CB, Milano, CA, Rogers, JG, Felker, GM, O'Connor, CM, Shah, SH, and Kraus, WE. "Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support." Journal of the American College of Cardiology 67, no. 3 (January 2016): 291-299. PMID: 26796394

Shah, SH, Arnett, D, Houser, SR, Ginsburg, GS, MacRae, C, Mital, S, Loscalzo, J, and Hall, JL. "Opportunities for the Cardiovascular Community in the Precision Medicine Initiative." Circulation 133, no. 2 (January 2016): 226-231. PMID: 27028435

Dungan, JR, Qin, X, Horne, BD, Carlquist, JF, Singh, A, Hurdle, M, Grass, E, Haynes, C, Gregory, SG, Shah, SH, Hauser, ER, and Kraus, WE. "Case-Only Survival Analysis Reveals Unique Effects of Genotype, Sex, and Coronary Disease Severity on Survivorship." PloS one 11, no. 5 (January 2016): e0154856-.PMID 27187494

"Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease." New England Journal of Medicine 374, no. 12 (March 24, 2016): 1134-1144.