My research integrates ideas from a number of scientific fields including evolutionary genetics, virology, ecology, and infectious disease epidemiology. I conduct human and animal disease surveillance, virus isolation and characterization (genetic and phenotypic), then conduct large-scale analyses to generate hypotheses that are tested in the laboratory using tissue culture and animal models. I am primarily interested in the roles played by mutation, natural selection, recombination/reassortment and host immune response on virus diversity within an individual, during transmission within a population and during inter-species transmission between hosts. I work mostly on influenza but also study a wide range of respiratory and enteric viruses. My research program is directed at efforts to better understand viral disease ecosystems in Asia, specifically the animal-human interface, to inform and enhance disease control.
Joseph U, Linster M, Suzuki Y, Krauss S, Halpin RA, Vijaykrishna D, Fabrizio TP, Bestebroer TM,Maurer-Stroh S, Webby RJ, Wentworth DE, Fouchier RAM, Bahl J, Smith GJD, and members of theCEIRS H2N2 Working Group (2014). Adaptation of pandemic H2N2 influenza A viruses in humans.Journal of Virology (In press).
Westgeest KB, de Graaf M, Bestebroer TM, van Beek R, Spronken MI, de Jong JC, Rimmelzwaan GF, Russell CA, Osterhaus ADME, Smith GJD, Smith DJ, Fouchier RAM (2012). The genetic evolution of neuraminidase of influenza A (H3N2) viruses from 1968 to 2009 and its correspondence to hemagglutinin. Journal of General Virology 93, 1996-2007.
Smith GJD, Bahl J, Vijaykrishna D (2012). Genetic analysis. Methods in Molecular Biology 865, 207-227.
Boni MF, Smith GJD, Holmes EC, Vijaykrishna D (2012). No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine. Gene 494, 242-245.
WHO/OIE/FAO H5N1 Evolution Working Group (2012). Continued evolution of highly pathogenic avian influenza A (H5N1): updated nomenclature. Influenza and other Respiratory Viruses 6, 1-5. [Committee Co-Chair]
Meijer A, van der Sanden S, Snijders BEP, Jaramillo-Gutierrez G, Bont L, van der Ent CK, Overduin P, Jennya SL, Jusic E, van der Avoort HGAM, Smith GJD, Donker GA, Koopmans MPG (2012). Emergence and epidemic occurrence of enterovirus 68 respiratory infections in the Netherlands in 2010. Virology 423, 49-57.
Bahl J, Nelson MI, Chan KH, Chen R, Vijaykrishna D, Halpin RA, Stockwell TB, Lin X, Wentworth DE, Ghedin E, Guan Y, Peiris JSM, Riley S, Rambaut A, Holmes EC, Smith GJD (2011). Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans. Proceedings of the National Academy of Sciences USA 108, 19359-19364.
Lessler J, Riley S, Read JM, Wang S, Zhu H, Smith GJD, Guan Y, Jiang CQ, Cummings DAT (2011). Evidence for antigenic seniority in influenza A (H3N2) antibody responses in southern China. PLoS Pathogens 8, 1002802.