Our Work

Antibiotic-resistant Enterobacteriaceae in community-acquired urinary tract infections, southern Sri Lanka

Project Objectives

Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae are increasingly reported as pathogens in urinary tract infections (UTIs). Infections due to ESBLs are worrisome as they are resistant to multiple antibiotics and can be difficult to treat. In Sri Lanka, the clinical and molecular epidemiology of ESBL-producing Enterobacteriaceae causing UTIs has not been well described. We conducted prospective, laboratory-based surveillance in a tertiary care hospital in southern Sri Lanka and enrolled patients %u22651 year with clinically relevant UTI due to ESBL-producing Enterobacteriaceae. Isolate identity, antimicrobial drug susceptibility, and ESBL production were detected and presence of ß-lactamase genes was identified by polymerase chain reaction. In this study, the majority of UTIs caused by ESBL-producing Enterobacteriaceae were acquired in the community and due to organisms carrying the group 1 CTX-M ß-lactamase. Further epidemiologic studies of ESBL-producing infections in South Asia are urgently needed to better prevent and treat these antibiotic-resistant infections.

Department & School

Medicine: Infectious Diseases
School of Medicine

Locations

Sponsors

  • NIH-Fogarty International Center

Project Status

Ongoing

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