There is an urgent need for global guidance on effective, culturally appropriate, and sustainable psychosocial interventions for mental disorders in low- and middle-income countries (LMICs). While the burden of mental illness in LMICs is now well established, there remains a significant treatment gap for mental disorders, particularly for psychotic disorders in sub-Saharan Africa. Family psychoeducation (FPE) is an evidence-based practice developed in high-income countries to help individuals with psychotic disorders and their relatives to cope more effectively with the illness; however, FPE has never been tested in a low-resource country nor have the mechanisms of action for this psychosocial intervention been fully identified. This project (2017-2020) will pilot test a culturally tailored Family Psychoeducation model (FamPE) for adults with psychotic disorders and their relatives. The study design includes formative research to adapt FPE and a small randomized controlled trial (RCT) with 72 patient/relative dyads to meet these specific aims: 1) Assess how family psychoeducation can improve client outcomes, engage families and address gaps in mental health services in Tanzania; 2) Culturally tailor the FamPE intervention for use in Tanzania; and 3) Pilot test the FamPE intervention and explore its impact on patient relapse, quality of life and disability. **Partners:** Muhimbili University of Health & Allied Sciences (MUHAS) in Tanzania and Columbia University in New York NY. **Funder:** National Institute of Mental Health (NIMH)