As health systems in high-income countries struggle to balance affordability, quality, and access to care, particularly for their most vulnerable populations, health innovations arising in low- and middle-income countries (LMICs) represent a source of ideas for new models of care and technologies to help address these challenges. Studying frugal health innovations globally through a systematic approach provides an opportunity to learn from the work of entrepreneurs employing novel methods and models of care in low- and middle-income countries and provides an avenue to identify promising new solutions for the US and elsewhere. Funding from the Commonwealth Fund will support IPIHD to identify, prioritize, and further analyze three models from its global network of health innovations that have the potential to address critical challenges facing the US healthcare system. Selected models would likely target high-need, high-cost patients and conditions as well as low-income patients and other vulnerable populations lacking affordable access to high quality care. Over the course of this 10-month project, IPIHD will work with the Commonwealth Fund to select three promising models and will develop in-depth case studies detailing various aspects of the operational processes, revenue structures, and patient populations supported by these models, as well as considerations related to how they might be adapted to the US context. These case studies will provide the Commonwealth Fund with greater understanding of the potential of these frugal innovations to be replicated in the US and will serve as a foundation for designing and implementing a US-based frugal innovation pilot.