The molecular landscape of lymphoma on the Indian sub-continent
Diffuse large B cell lymphoma is the most common form of lymphoma and exhibits a striking clinical heterogeneity. Although some patients are cured with standard multi-agent chemotherapy, over half the patients experience early progression, relapse and death from the disease, when treated with the same regimen. Gene expression profiling has revealed that the disease DLBCL harbors at least 2 molecularly and clinically distinct diseases with strikingly different responses to treatment. The extent to which these molecular groups occur in the Indian sub-continent is unknown. The primary goals of the current proposal are to develop the capacity for prospective tissue collection through collaboration with Dr. Manju Sengar at Tata Memorial Hospital in Mumbai, India and to develop a preliminary characterization of DLBCLs occurring in India. In doing so, we will develop the basis for externally funded projects that lay the groundwork for a sustainable and long-term partnership.