Our Work

Racial differences in the epidemiology of cervical neoplasia and HPV distribution in Brazil: A prospective, cross-sectional study

Project Objectives

Cervical cancer remains a leading cause of cancer among women worldwide and outcomes in individuals of African descent remain worse at multiple points in the health care continuum- even when accounting for disease stage at diagnosis and similar screening rates.

Researchers at Duke University (Laura Musselwhite), the UNC Gillings School of Public Health (Jennifer Smith), and Barretos Cancer Hospital (José Humberto Fregnani), are conducting a prospective study of 500 women referred for colposcopy in Barretos, Brazil. This study offers a biological approach to exploring racial disparities using an innovative platform for establishing genetic ancestrality and its role in cervical neoplasia. Secondary objectives include the evaluation of HPV vaccine knowledge and acceptability among a high-risk group of women in Brazil and the establishment of a well-described cohort of women with a biorepository of specimens for future molecular biology and genetic research.

Project Outcomes

500 cases have been collected. Data analysis on going

Faculty

Department & School

Medicine: Cellular Therapy
School of Medicine

Locations

Sponsors

  • Bill & Melinda Gates Foundation

Collaborators

  • UNC Gillings School of Public Health
  • Barretos Cancer Hospital

Project Status

Ongoing

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