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Barton Haynes

Frederic M. Hanes Professor, Medicine and Immunology and Global Health
Director, Duke Human Vaccine Institute and the Center for HIV-AIDS Vaccine Immunology
School of Medicine
Bart Haynes


There are three main research interests in the Haynes laboratory. One group focuses on the basic mechanisms of T cell development with regard to thymocyte-thymic stromal interactions, and on the role the thymic microenvironment plays in regulating thymic growth and atrophy in a variety of settings. The overall goal of this project is to understand the mechanisms of thymic atrophy and T cell homeostasis in order to devise new strategies to reconstitute the T cell arm of the immune system in congenital and acquired immune deficiency diseases.

The second group works on the role of T Regulatory Cells in regulating immune responses and the role of CD7 and CD7 ligand in T regulatory cell production and homeostasis.

The third group is involved in Preclinical/Clinical AIDS Vaccine Development. The overall goal of this project is to design and develop novel immunogens and adjuvants for testing as experimental HIV vaccines. The Haynes laboratory has led the way over the years in developing peptide immunogens reflective of important functional regions of the HIV envelope and other HIV proteins that might be used in the design of peptide/DNA strategies for both protection and treatment of HIV infection. Current work centers on devising strategies using both systemic and mucosal immunization with peptide immunogens for the development of preventive and therapeutic immunogens for HIV infection. Dr. Haynes is the Director of the Duke University Human Vaccine Institute.

Recent Publications

Krebs, SJ, Kwon, YD, Schramm, CA, Law, WH, Donofrio, G, Zhou, KH, Gift, S, Dussupt, V, Georgiev, IS, Schätzle, S, McDaniel, JR, Lai, Y-T, Sastry, M, Zhang, B, Jarosinski, MC, Ransier, A, Chenine, AL, Asokan, M, Bailer, RT, Bose, M, Cagigi, A, Cale, EM, Chuang, G-Y, Darko, S, Driscoll, JI, Druz, A, Gorman, J, Laboune, F, Louder, MK, McKee, K, Mendez, L, Moody, MA, O'Sullivan, AM, Owen, C, Peng, D, Rawi, R, Sanders-Buell, E, Shen, C-H, Shiakolas, AR, Stephens, T, Tsybovsky, Y, Tucker, C, Verardi, R, Wang, K, Zhou, J, Zhou, T, Georgiou, G, Alam, SM, Haynes, BF, Rolland, M, Matyas, GR, Polonis, VR, McDermott, AB, Douek, DC, Shapiro, L, Tovanabutra, S, Michael, NL, Mascola, JR, Robb, ML, Kwong, PD, & Doria-Rose, NA. (2019, March 12). Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity, 50 (3), 677-691.e13.
Petitdemange, C, Kasturi, SP, Kozlowski, PA, Nabi, R, Quarnstrom, CF, Reddy, PBJ, Derdeyn, CA, Spicer, LM, Patel, P, Legere, T, Kovalenkov, YO, Labranche, CC, Villinger, F, Tomai, M, Vasilakos, J, Haynes, B, Kang, CY, Gibbs, JS, Yewdell, JW, Barouch, D, Wrammert, J, Montefiori, D, Hunter, E, Amara, RR, Masopust, D, & Pulendran, B. (2019, February 21). Vaccine induction of antibodies and tissue-resident CD8+ T cells enhances protection against mucosal SHIV-infection in young macaques. Jci Insight, 4 (4).
Kisalu, NK, Idris, AH, Weidle, C, Flores-Garcia, Y, Flynn, BJ, Sack, BK, Murphy, S, Schön, A, Freire, E, Francica, JR, Miller, AB, Gregory, J, March, S, Liao, H-X, Haynes, BF, Wiehe, K, Trama, AM, Saunders, KO, Gladden, MA, Monroe, A, Bonsignori, M, Kanekiyo, M, Wheatley, AK, McDermott, AB, Farney, SK, Chuang, G-Y, Zhang, B, Kc, N, Chakravarty, S, Kwong, PD, Sinnis, P, Bhatia, SN, Kappe, SHI, Sim, BKL, Hoffman, SL, Zavala, F, Pancera, M, & Seder, RA. (2019, January). Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. Nature Medicine, 25 (1), 188-189.
Bricault, CA, Yusim, K, Seaman, MS, Yoon, H, Theiler, J, Giorgi, EE, Wagh, K, Theiler, M, Hraber, P, Macke, JP, Kreider, EF, Learn, GH, Hahn, BH, Scheid, JF, Kovacs, JM, Shields, JL, Lavine, CL, Ghantous, F, Rist, M, Bayne, MG, Neubauer, GH, McMahan, K, Peng, H, Chéneau, C, Jones, JJ, Zeng, J, Ochsenbauer, C, Nkolola, JP, Stephenson, KE, Chen, B, Gnanakaran, S, Bonsignori, M, Williams, LD, Haynes, BF, Doria-Rose, N, Mascola, JR, Montefiori, DC, Barouch, DH, & Korber, B. (2019, January). HIV-1 Neutralizing Antibody Signatures and Application to Epitope-Targeted Vaccine Design. Cell Host & Microbe, 25 (1), 59-72.e8.
Bonsignori, M, Scott, E, Wiehe, K, Easterhoff, D, Alam, SM, Hwang, K-K, Cooper, M, Xia, S-M, Zhang, R, Montefiori, DC, Henderson, R, Nie, X, Kelsoe, G, Moody, MA, Chen, X, Joyce, MG, Kwong, PD, Connors, M, Mascola, JR, McGuire, AT, Stamatatos, L, Medina-Ramírez, M, Sanders, RW, Saunders, KO, Kepler, TB, & Haynes, BF. (2018, December 11). Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier. Immunity, 49 (6), 1162-1174.e8.
van Eeden, C, Wibmer, CK, Scheepers, C, Richardson, SI, Nonyane, M, Lambson, B, Mkhize, NN, Vijayakumar, B, Sheng, Z, Stanfield-Oakley, S, Bhiman, JN, Bekker, V, Hermanus, T, Mabvakure, B, Ismail, A, Moody, MA, Wiehe, K, Garrett, N, Karim, SA, Dirr, H, Fernandes, MA, Sayed, Y, Shapiro, L, Ferrari, G, Haynes, BF, Moore, PL, & Morris, L. (2018, December). V2-Directed Vaccine-like Antibodies from HIV-1 Infection Identify an Additional K169-Binding Light Chain Motif with Broad ADCC Activity. Cell Reports, 25 (11), 3123-3135.e6.

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