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Faculty

Barton Haynes

Frederic M. Hanes Professor, Medicine and Immunology and Global Health
Director, Duke Human Vaccine Institute and the Center for HIV-AIDS Vaccine Immunology
School of Medicine
Bart Haynes

Summary

There are three main research interests in the Haynes laboratory. One group focuses on the basic mechanisms of T cell development with regard to thymocyte-thymic stromal interactions, and on the role the thymic microenvironment plays in regulating thymic growth and atrophy in a variety of settings. The overall goal of this project is to understand the mechanisms of thymic atrophy and T cell homeostasis in order to devise new strategies to reconstitute the T cell arm of the immune system in congenital and acquired immune deficiency diseases.

The second group works on the role of T Regulatory Cells in regulating immune responses and the role of CD7 and CD7 ligand in T regulatory cell production and homeostasis.

The third group is involved in Preclinical/Clinical AIDS Vaccine Development. The overall goal of this project is to design and develop novel immunogens and adjuvants for testing as experimental HIV vaccines. The Haynes laboratory has led the way over the years in developing peptide immunogens reflective of important functional regions of the HIV envelope and other HIV proteins that might be used in the design of peptide/DNA strategies for both protection and treatment of HIV infection. Current work centers on devising strategies using both systemic and mucosal immunization with peptide immunogens for the development of preventive and therapeutic immunogens for HIV infection. Dr. Haynes is the Director of the Duke University Human Vaccine Institute.

Recent Publications

Kisalu, NK, Idris, AH, Weidle, C, Flores-Garcia, Y, Flynn, BJ, Sack, BK, Murphy, S, Schön, A, Freire, E, Francica, JR, Miller, AB, Gregory, J, March, S, Liao, H-X, Haynes, BF, Wiehe, K, Trama, AM, Saunders, KO, Gladden, MA, Monroe, A, Bonsignori, M, Kanekiyo, M, Wheatley, AK, McDermott, AB, Farney, SK, Chuang, G-Y, Zhang, B, Kc, N, Chakravarty, S, Kwong, PD, Sinnis, P, Bhatia, SN, Kappe, SHI, Sim, BKL, Hoffman, SL, Zavala, F, Pancera, M, & Seder, RA. (2018, May). A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. (Accepted) Nature medicine, 24 (4), 408-416.
Saunders, KO, Santra, S, Parks, R, Yates, NL, Sutherland, LL, Scearce, RM, Balachandran, H, Bradley, T, Goodman, D, Eaton, A, Stanfield-Oakley, SA, Tartaglia, J, Phogat, S, Pantaleo, G, Esteban, M, Gomez, CE, Perdiguero, B, Jacobs, B, Kibler, K, Korber, B, Montefiori, DC, Ferrari, G, Vandergrift, N, Liao, H-X, Tomaras, GD, & Haynes, BF. (2018, April). Immunogenicity of NYVAC Prime-Protein Boost Human Immunodeficiency Virus Type 1 Envelope Vaccination and Simian-Human Immunodeficiency Virus Challenge of Nonhuman Primates. Journal of virology, 92 (8).
Fong, Y, Shen, X, Ashley, VC, Deal, A, Seaton, KE, Yu, C, Grant, SP, Ferrari, G, deCamp, AC, Bailer, RT, Koup, RA, Montefiori, D, Haynes, BF, Sarzotti-Kelsoe, M, Graham, BS, Carpp, LN, Hammer, SM, Sobieszczyk, M, Karuna, S, Swann, E, DeJesus, E, Mulligan, M, Frank, I, Buchbinder, S, Novak, RM, McElrath, MJ, Kalams, S, Keefer, M, Frahm, NA, Janes, HE, Gilbert, PB, & Tomaras, GD. (2018, March). Modification of the Association Between T-Cell Immune Responses and Human Immunodeficiency Virus Type 1 Infection Risk by Vaccine-Induced Antibody Responses in the HVTN 505 Trial. The Journal of infectious diseases, 217 (8), 1280-1288.
Malherbe, DC, Mendy, J, Vang, L, Barnette, PT, Reed, J, Lakhashe, SK, Owuor, J, Gach, JS, Legasse, AW, Axthelm, MK, LaBranche, CC, Montefiori, D, Forthal, DN, Park, B, Wilson, JM, McLinden, JH, Xiang, J, Stapleton, JT, Sacha, JB, Haynes, BF, Liao, H-X, Ruprecht, RM, Smith, J, Gurwith, M, Haigwood, NL, & Alexander, J. (2018, January). Combination Adenovirus and Protein Vaccines Prevent Infection or Reduce Viral Burden after Heterologous Clade C Simian-Human Immunodeficiency Virus Mucosal Challenge. Journal of virology, 92 (2).
Seaton, KE, Vandergrift, NA, Deal, AW, Rountree, W, Bainbridge, J, Grebe, E, Anderson, DA, Sawant, S, Shen, X, Yates, NL, Denny, TN, Liao, H-X, Haynes, BF, Robb, ML, Parkin, N, Santos, BR, Garrett, N, Price, MA, Naniche, D, Duerr, AC, CEPHIA group, , Keating, S, Hampton, D, Facente, S, Marson, K, Welte, A, Pilcher, CD, Cohen, MS, & Tomaras, GD. (2017, December 21). Computational analysis of antibody dynamics identifies recent HIV-1 infection. JCI insight, 2 (24).

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