Sallie Permar

Professor, Pediatrics

Professor, Immunology

Professor, Molecular Genetics and Microbiology

Dr. Permar's work focuses on maternal correlates of immune protection against vertical transmission of neonatal viral pathogens. She has utilized the nonhuman primate model of HIV/AIDS, Simian Immunodeficiency Virus (SIV) infection of rhesus monkeys, to characterize the virus-specific immune responses and virus evolution in breast milk. Furthermore, the Permar lab is characterizing HIV/SIV vaccine-elicited immune responses in breast milk of vaccinated rhesus monkeys, as a platform for developing a maternal vaccine regimen for protection against breast milk transmission of HIV. In addition, Dr. Permar's lab has advanced the understanding of HIV-specific immune responses and virus evolution in vertically-transmitting and nontransmitting HIV-infected women, defining maternal immune responses that may protect against neonatal transmission of HIV. Finally, Dr. Permar has established studies of maternal cytomegalovirus-specific immune responses that may protect against symptomatic congenital cytomegalovirus and postnatal transmission in preterm infants.