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Genetic Epidemiology of Cardiomyopathy


August 01, 2008 - July 01, 2009

Project Objectives

Cardiomyopathy is a disease of heart muscle that is endemic in Africa. Various forms of cardiomyopathy including arryhthmogenic right ventricular cardiomyopathy, peripartum cardiomyopathy, and idiopathic cardiomyopathy are significant causes of morbidity and mortality in Africa; yet their prevalence, etiologies, and optimal treatments are poorly understood. The aim of the present study is to compile a nationwide database of patients with these cardiomyopathies in South Africa to quantify their epidemiology more rigorously. Special attention will be paid to the genetic risk factors of the various cardiomyopathies, since they have been reported to cluster in families. Results of the analysis of baseline characteristics of patients in this database will eventually be used to design prospective studies to observe the natural history of cardiomyopathy in this cohort, as well as to establish an evidence base for optimal treatment.

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