Tazeen H. Jafar
Research Professor of Global Health
Professor Health Services & Systems Research
Duke-NUS Graduate Medical School Singapore
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Tazeen H. Jafar
Research Professor of Global Health
Professor Health Services & Systems Research
Duke-NUS Graduate Medical School Singapore
Dr. Tazeen Jafar is a global health leader and expert with a focus on implementation research in hypertension, cardiovascular disease, and chronic kidney disease.
Dr Jafar is Professor of Health Services and Systems Research at Duke-NUS Medical School, Singapore, Visiting Consultant Renal Medicine at Singapore General Hospital, Visiting Professor of Medicine, Aga Khan University, Karachi, Pakistan, Adjunct Professor of Nephrology, Tufts Medical Center, Boston, MA, USA, and Research Professor at Duke Global Health Institute, Durham, NC, USA.
Professor Jafar went to medical school at the Aga Khan University, Karachi, Pakistan, followed by residency in Medicine-Pediatrics (and dual board certification) from University of Texas Health Science Center at Houston, and fellowship in clinical nephrology (with board certification in Nephrology) and clinical research at Tufts Medical Center, Boston. She also obtained Masters in Public Health from Harvard University.
Professor Jafar has been leading innovative, impactful, research funded by Wellcome Trust, UK, NIH-Fogarty, MRC, DfID, and Singapore National Ministry of Health in chronic non-communicable diseases in global health settings for over 15 years. She is the chief principal investigator and executive director of the multi-country COBRA-BPS (Control of Blood Pressure and Risk Attenuation-Bangladesh, Pakistan, Sri Lanka) trial coordinated at Duke-NUS Medical School Singapore in 30 rural villages through the public sector in three South Asian countries https://www.facebook.com/cobra.bps/ The trial is funded by the UK-MRC/Wellcome Trust, DfID, and evaluated a community health workers-led multicomponent intervention on standardized hypertension care including door to door proactive BP screening and lifestyle coaching by trained government community health workers and referral to trained physicians at clinics with triage counter, and care coordinators vs usual care in rural low- and middle- income country (LMIC) setting. The findings from COBRA-BPS trial showing benefit of the intervention strategies on clinically meaningful reduction in BP and demonstrating validity of the approach in a variety of settings have been published in the New England Journal of Medicine.
Professor Jafar is the recipient of the International Society of Hypertension 2012 Boehringer Ingelheim Developing World Award.
Funded by the Singapore National Medical Research Council, Prof Jafar designed the SingHypertension cluster RCT- first cluster randomized trial of its kind for improving management of hypertension in advanced public sector polyclinics in Singapore. She is also the co-theme PI on A*STAR funded “Diabetes Clinic of the Future” project in Singapore.
Professor Jafar mentors several junior faculty, post-docs, graduate students, and medical students in conducting meaningful research and data analyses (SingHealth polyclinic data, Singapore Renal Registry, Singapore Chinese Health Study), and has facilitated acquisition of training grants. She is a Council member of International Society of Hypertension Asia Pacific Region. Dr Jafar is also a practicing nephrologist.
Publications
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Rhee CM, CJASN Editorial Team. CJASN: A Prelude to the Future. Clin J Am Soc Nephrol. 2024 Nov 7;Jafar TH, Tan NC, Gandhi M, Yoon S, Finkelstein E, Seng PMK, et al. Evaluating a multicomponent intervention for managing kidney outcomes among patients with moderate or advanced chronic kidney disease (CKD): protocol for the Strategies for Kidney Outcomes Prevention and Evaluation (SKOPE) randomized controlled trial. Trials. 2024 Oct 30;25(1):730.Heerspink HJL, Eddington D, Chaudhari J, Estacio R, Imai E, Goicoechea M, et al. A meta-analysis of randomized controlled clinical trials for implications of acute treatment effects on glomerular filtration rate for long-term kidney protection. Kidney international. 2024 Oct;106(4):688–98.Ku E, Tighiouart H, McCulloch CE, Inker LA, Adingwupu OM, Greene T, et al. Association between Acute Declines in eGFR during Renin-Angiotensin System Inhibition and Risk of Adverse Outcomes. Journal of the American Society of Nephrology : JASN. 2024 Oct;35(10):1402–11.
See more publications at Scholars@Duke