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Affiliate Faculty

Georgia Tomaras

Professor (with tenure), Department of Surgery
Professor, Department of Immunology
Professor, Department of Molecular Genetics and Microbiology
School of Medicine
Surgery: Surgical Sciences

(919) 681-5598

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Georgia Tomaras


Dr. Tomaras' overall research program is to understand the cellular and humoral immune response to HIV-1 infection and vaccination that are involved in protection from HIV-1. The research in the Tomaras laboratory centers around three main projects involving 1) antiviral CD8 T cell responses in HIV-1 infection and post vaccination, 2) mucosal and systemic antibody responses to infection and vaccination in both non-human primates and humans and 3) the ontogeny of neutralizing antibodies in HIV-1 infection. Her laboratory is also within the Duke Human Vaccine Institute.



Recent Publications

Wiehe, K, Nicely, NI, Lockwood, B, Kuraoka, M, Anasti, K, Arora, S, Bowman, CM, Stolarchuk, C, Parks, R, Lloyd, KE, Xia, SM, Duffy, R, Shen, X, Kyratsous, CA, Macdonald, LE, Murphy, AJ, Scearce, RM, Moody, MA, Alam, SM, Verkoczy, L, Tomaras, GD, Kelsoe, G, and Haynes, BF. "Immunodominance of Antibody Recognition of the HIV Envelope V2 Region in Ig-Humanized Mice." Journal of immunology (Baltimore, Md. : 1950) 198, no. 3 (February 2017): 1047-1055.

Chang, WL, Gonzalez, DF, Kieu, HT, Castillo, LD, Messaoudi, I, Shen, X, Tomaras, GD, Shacklett, BL, Barry, PA, and Sparger, EE. "Changes in Circulating B Cell Subsets Associated with Aging and Acute SIV Infection in Rhesus Macaques." PloS one 12, no. 1 (January 17, 2017): e0170154

Bolton, DL, Song, K, Tomaras, GD, Rao, S, and Roederer, M. "Unique cellular and humoral immunogenicity profiles generated by aerosol, intranasal, or parenteral vaccination in rhesus macaques." Vaccine (December 29, 2016).

Luo, K, Liao, HX, Zhang, R, Easterhoff, D, Wiehe, K, Gurley, TC, Armand, LC, Allen, AA, Von Holle, TA, Marshall, DJ, Whitesides, JF, Pritchett, J, Foulger, A, Hernandez, G, Parks, R, Lloyd, KE, Stolarchuk, C, Sawant, S, Peel, J, Yates, NL, Dunford, E, Arora, S, Wang, A, Bowman, CM, Sutherland, LL, Scearce, RM, Xia, SM, Bonsignori, M, Pollara, J, Edwards, RW, Santra, S, Letvin, NL, Tartaglia, J, Francis, D, Sinangil, F, Lee, C, Kaewkungwal, J, Nitayaphan, S, Pitisuttithum, P, and Rerks-Ngarm, S et al. "Tissue memory B cell repertoire analysis after ALVAC/AIDSVAX B/E gp120 immunization of rhesus macaques." JCI insight 1, no. 20 (December 8, 2016): e88522

Astronomo, RD, Santra, S, Ballweber-Fleming, L, Westerberg, KG, Mach, L, Hensley-McBain, T, Sutherland, L, Mildenberg, B, Morton, G, Yates, NL, Mize, GJ, Pollara, J, Hladik, F, Ochsenbauer, C, Denny, TN, Warrier, R, Rerks-Ngarm, S, Pitisuttithum, P, Nitayapan, S, Kaewkungwal, J, Ferrari, G, Shaw, GM, Xia, SM, Liao, HX, Montefiori, DC, Tomaras, GD, Haynes, BF, and McElrath, JM. "Neutralization Takes Precedence Over IgG or IgA Isotype-related Functions in Mucosal HIV-1 Antibody-mediated Protection." EBioMedicine 14 (December 2016): 97-111.

Ferrari, G, Haynes, BF, Koenig, S, Nordstrom, JL, Margolis, DM, and Tomaras, GD. "Envelope-specific antibodies and antibody-derived molecules for treating and curing HIV infection." Nature reviews. Drug discovery 15, no. 12 (December 2016): 823-834.

Negri, D, Blasi, M, LaBranche, C, Parks, R, Balachandran, H, Lifton, M, Shen, X, Denny, T, Ferrari, G, Vescio, MF, Andersen, H, Montefiori, DC, Tomaras, GD, Liao, H-X, Santra, S, Haynes, BF, Klotman, ME, and Cara, A. "Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques." MOLECULAR THERAPY 24, no. 11 (November 2016): 2021-2032.

Negri, D, Blasi, M, LaBranche, C, Parks, R, Balachandran, H, Lifton, M, Shen, X, Denny, T, Ferrari, G, Vescio, MF, Andersen, H, Montefiori, DC, Tomaras, GD, Liao, HX, Santra, S, Haynes, BF, Klotman, ME, and Cara, A. "Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques." Molecular therapy : the journal of the American Society of Gene Therapy 24, no. 11 (November 2016): 2021-2032.

Andersson, AC, Ragonnaud, E, Seaton, KE, Sawant, S, Folgori, A, Colloca, S, Labranche, C, Montefiori, DC, Tomaras, GD, and Holst, PJ. "Effect of HIV-1 envelope cytoplasmic tail on adenovirus primed virus encoded virus-like particle immunizations." Vaccine 34, no. 44 (October 2016): 5344-5351.

Gordon, SN, Liyanage, NP, Doster, MN, Vaccari, M, Vargas-Inchaustegui, DA, Pegu, P, Schifanella, L, Shen, X, Tomaras, GD, Rao, M, Billings, EA, Schwartz, J, Prado, I, Bobb, K, Zhang, W, Montefiori, DC, Foulds, KE, Ferrari, G, Robert-Guroff, M, Roederer, M, Phan, TB, Forthal, DN, Stablein, DM, Phogat, S, Venzon, DJ, Fouts, T, and Franchini, G. "Boosting of ALVAC-SIV Vaccine-Primed Macaques with the CD4-SIVgp120 Fusion Protein Elicits Antibodies to V2 Associated with a Decreased Risk of SIVmac251 Acquisition." Journal of immunology (Baltimore, Md. : 1950) 197, no. 7 (October 2016): 2726-2737.

Iyer, SS, Gangadhara, S, Victor, B, Shen, X, Chen, X, Nabi, R, Kasturi, SP, Sabula, MJ, Labranche, CC, Reddy, PB, Tomaras, GD, Montefiori, DC, Moss, B, Spearman, P, Pulendran, B, Kozlowski, PA, and Amara, RR. "Virus-Like Particles Displaying Trimeric Simian Immunodeficiency Virus (SIV) Envelope gp160 Enhance the Breadth of DNA/Modified Vaccinia Virus Ankara SIV Vaccine-Induced Antibody Responses in Rhesus Macaques." Journal of virology 90, no. 19 (October 2016): 8842-8854.

Safrit, JT, Tomaras, GD, Hanke, T, deCamp, AC, and Voronin, Y. "The Landscape of Targeted Immune Responses in the HIV-1 Vaccine Field." AIDS research and human retroviruses 32, no. 10-11 (October 2016): 944-946.

Townsley, S, Mohamed, Z, Guo, W, McKenna, J, Cleveland, B, LaBranche, C, Beaumont, D, Shen, X, Yates, NL, Pinter, A, Tomaras, GD, Ferrari, G, Montefiori, DC, and Hu, SL. "Induction of Heterologous Tier 2 HIV-1-Neutralizing and Cross-Reactive V1/V2-Specific Antibodies in Rabbits by Prime-Boost Immunization." Journal of virology 90, no. 19 (October 2016): 8644-8660.

Tay, MZ, Liu, P, Williams, LD, McRaven, MD, Sawant, S, Gurley, TC, Xu, TT, Dennison, SM, Liao, HX, Chenine, AL, Alam, SM, Moody, MA, Hope, TJ, Haynes, BF, and Tomaras, GD. "Antibody-Mediated Internalization of Infectious HIV-1 Virions Differs among Antibody Isotypes and Subclasses." PLoS pathogens 12, no. 8 (August 31, 2016): e1005817

Abdulhaqq, SA, Zorrilla, C, Kang, G, Yin, X, Tamayo, V, Seaton, KE, Joseph, J, Garced, S, Tomaras, GD, Linn, KA, Foulkes, AS, Azzoni, L, VerMilyea, M, Coutifaris, C, Kossenkov, AV, Showe, L, Kraiselburd, EN, Li, Q, and Montaner, LJ. "HIV-1-negative female sex workers sustain high cervical IFN%u025B, low immune activation, and low expression of HIV-1-required host genes." Mucosal immunology 9, no. 4 (July 2016): 1027-1038.

Vaccari, M, Gordon, SN, Fourati, S, Schifanella, L, Liyanage, NP, Cameron, M, Keele, BF, Shen, X, Tomaras, GD, Billings, E, Rao, M, Chung, AW, Dowell, KG, Bailey-Kellogg, C, Brown, EP, Ackerman, ME, Vargas-Inchaustegui, DA, Whitney, S, Doster, MN, Binello, N, Pegu, P, Montefiori, DC, Foulds, K, Quinn, DS, Donaldson, M, Liang, F, Loré, K, Roederer, M, Koup, RA, McDermott, A, Ma, ZM, Miller, CJ, Phan, TB, Forthal, DN, Blackburn, M, Caccuri, F, Bissa, M, Ferrari, G, Kalyanaraman, V, and Ferrari, MG et al. "Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition." Nature medicine 22, no. 7 (July 2016): 762-770.

Gray, GE, Mayer, KH, Elizaga, ML, Bekker, LG, Allen, M, Morris, L, Montefiori, D, De Rosa, SC, Sato, A, Gu, N, Tomaras, GD, Tucker, T, Barnett, SW, Mkhize, NN, Shen, X, Downing, K, Williamson, C, Pensiero, M, Corey, L, and Williamson, AL. "Subtype C gp140 Vaccine Boosts Immune Responses Primed by the South African AIDS Vaccine Initiative DNA-C2 and MVA-C HIV Vaccines after More than a 2-Year Gap." Clinical and vaccine immunology : CVI 23, no. 6 (June 2016): 496-506.

Le Grand, R, Dereuddre-Bosquet, N, Dispinseri, S, Gosse, L, Desjardins, D, Shen, X, Tolazzi, M, Ochsenbauer, C, Saidi, H, Tomaras, G, Prague, M, Barnett, SW, Thiebaut, R, Cope, A, Scarlatti, G, and Shattock, RJ. "Superior Efficacy of a Human Immunodeficiency Virus Vaccine Combined with Antiretroviral Prevention in Simian-Human Immunodeficiency Virus-Challenged Nonhuman Primates." Journal of virology 90, no. 11 (June 2016): 5315-5328.

Li, H, Wang, S, Kong, R, Ding, W, Lee, FH, Parker, Z, Kim, E, Learn, GH, Hahn, P, Policicchio, B, Brocca-Cofano, E, Deleage, C, Hao, X, Chuang, GY, Gorman, J, Gardner, M, Lewis, MG, Hatziioannou, T, Santra, S, Apetrei, C, Pandrea, I, Alam, SM, Liao, HX, Shen, X, Tomaras, GD, Farzan, M, Chertova, E, Keele, BF, Estes, JD, Lifson, JD, Doms, RW, Montefiori, DC, Haynes, BF, Sodroski, JG, Kwong, PD, Hahn, BH, and Shaw, GM. "Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques." Proceedings of the National Academy of Sciences of the United States of America 113, no. 24 (June 2016): E3413-E3422.

O'Connell, RJ, Excler, JL, Polonis, VR, Ratto-Kim, S, Cox, J, Jagodzinski, LL, Liu, M, Wieczorek, L, McNeil, JG, El-Habib, R, Michael, NL, Gilliam, BL, Paris, R, VanCott, TC, Tomaras, GD, Birx, DL, Robb, ML, and Kim, JH. "Safety and Immunogenicity of a Randomized Phase 1 Prime-Boost Trial With ALVAC-HIV (vCP205) and Oligomeric Glycoprotein 160 From HIV-1 Strains MN and LAI-2 Adjuvanted in Alum or Polyphosphazene." The Journal of infectious diseases 213, no. 12 (June 2016): 1946-1954.

Archary, D, Seaton, KE, Passmore, JS, Werner, L, Deal, A, Dunphy, LJ, Arnold, KB, Yates, NL, Lauffenburger, DA, Bergin, P, Liebenberg, LJ, Samsunder, N, Mureithi, MW, Altfeld, M, Garrett, N, Abdool Karim, Q, Abdool Karim, SS, Morris, L, and Tomaras, GD. "Distinct genital tract HIV-specific antibody profiles associated with tenofovir gel." Mucosal immunology 9, no. 3 (May 2016): 821-833.

Nelson, CS, Pollara, J, Kunz, EL, Jeffries, TL, Duffy, R, Beck, C, Stamper, L, Wang, M, Shen, X, Pickup, DJ, Staats, HF, Hudgens, MG, Kepler, TB, Montefiori, DC, Moody, MA, Tomaras, GD, Liao, HX, Haynes, BF, Ferrari, G, Fouda, GG, and Permar, SR. "Combined HIV-1 Envelope Systemic and Mucosal Immunization of Lactating Rhesus Monkeys Induces a Robust Immunoglobulin A Isotype B Cell Response in Breast Milk." Journal of virology 90, no. 10 (May 2016): 4951-4965.

Asbach, B, Kliche, A, Köstler, J, Perdiguero, B, Esteban, M, Jacobs, BL, Montefiori, DC, LaBranche, CC, Yates, NL, Tomaras, GD, Ferrari, G, Foulds, KE, Roederer, M, Landucci, G, Forthal, DN, Seaman, MS, Hawkins, N, Self, SG, Sato, A, Gottardo, R, Phogat, S, Tartaglia, J, Barnett, SW, Burke, B, Cristillo, AD, Weiss, DE, Francis, J, Galmin, L, Ding, S, Heeney, JL, Pantaleo, G, and Wagner, R. "Potential To Streamline Heterologous DNA Prime and NYVAC/Protein Boost HIV Vaccine Regimens in Rhesus Macaques by Employing Improved Antigens." Journal of virology 90, no. 8 (April 2016): 4133-4149.

Huang, Y, DiazGranados, C, Janes, H, Huang, Y, deCamp, AC, Metch, B, Grant, S, Sanchez, B, Phogat, S, Koutsoukos, M, Kanesa-Thasan, N, Bourguignon, P, Collard, A, Buchbinder, S, Tomaras, GD, McElrath, J, Gray, G, Kublin, JG, Corey, L, and Gilbert, PB. "Selection of HIV vaccine candidates for concurrent testing in an efficacy trial." Current opinion in virology 17 (April 2016): 57-65. (Review)

Mkhize, NN, Durgiah, R, Ashley, V, Archary, D, Garrett, NJ, Karim, QA, Karim, SS, Moore, PL, Yates, N, Passmore, JA, Tomaras, GD, and Morris, L. "Broadly neutralizing antibody specificities detected in the genital tract of HIV-1 infected women." AIDS (London, England) 30, no. 7 (April 2016): 1005-1014.

Zhang, R, Verkoczy, L, Wiehe, K, Munir Alam, S, Nicely, NI, Santra, S, Bradley, T, Pemble, CW, Zhang, J, Gao, F, Montefiori, DC, Bouton-Verville, H, Kelsoe, G, Larimore, K, Greenberg, PD, Parks, R, Foulger, A, Peel, JN, Luo, K, Lu, X, Trama, AM, Vandergrift, N, Tomaras, GD, Kepler, TB, Moody, MA, Liao, HX, and Haynes, BF. "Initiation of immune tolerance-controlled HIV gp41 neutralizing B cell lineages." Science translational medicine 8, no. 336 (April 2016): 336ra62

Havenar-Daughton, C, Lindqvist, M, Heit, A, Wu, JE, Reiss, SM, Kendric, K, Bélanger, S, Kasturi, SP, Landais, E, Akondy, RS, McGuire, HM, Bothwell, M, Vagefi, PA, Scully, E, Tomaras, GD, Davis, MM, Poignard, P, Ahmed, R, Walker, BD, Pulendran, B, McElrath, MJ, Kaufmann, DE, and Crotty, S. "CXCL13 is a plasma biomarker of germinal center activity." Proceedings of the National Academy of Sciences of the United States of America 113, no. 10 (March 2016): 2702-2707.

Walsh, SR, Moodie, Z, Fiore-Gartland, AJ, Morgan, C, Wilck, MB, Hammer, SM, Buchbinder, SP, Kalams, SA, Goepfert, PA, Mulligan, MJ, Keefer, MC, Baden, LR, Swann, EM, Grant, S, Ahmed, H, Li, F, Hertz, T, Self, SG, Friedrich, D, Frahm, N, Liao, HX, Montefiori, DC, Tomaras, GD, McElrath, MJ, Hural, J, Graham, BS, and Jin, X. "Vaccination With Heterologous HIV-1 Envelope Sequences and Heterologous Adenovirus Vectors Increases T-Cell Responses to Conserved Regions: HVTN 083." The Journal of infectious diseases 213, no. 4 (February 2016): 541-550.

Churchyard, G, Mlisana, K, Karuna, S, Williamson, AL, Williamson, C, Morris, L, Tomaras, GD, De Rosa, SC, Gilbert, PB, Gu, N, Yu, C, Mkhize, NN, Hermanus, T, Allen, M, Pensiero, M, Barnett, SW, Gray, G, Bekker, LG, Montefiori, DC, Kublin, J, and Corey, L. "Sequential Immunization with gp140 Boosts Immune Responses Primed by Modified Vaccinia Ankara or DNA in HIV-Uninfected South African Participants." PloS one 11, no. 9 (January 2016): e0161753

Cosgrove, CA, Lacey, CJ, Cope, AV, Bartolf, A, Morris, G, Yan, C, Baden, S, Cole, T, Carter, D, Brodnicki, E, Shen, X, Joseph, S, DeRosa, SC, Peng, L, Yu, X, Ferrari, G, Seaman, M, Montefiori, DC, Frahm, N, Tomaras, GD, Stöhr, W, McCormack, S, and Shattock, RJ. "Comparative Immunogenicity of HIV-1 gp140 Vaccine Delivered by Parenteral, and Mucosal Routes in Female Volunteers; MUCOVAC2, A Randomized Two Centre Study." PloS one 11, no. 5 (January 2016): e0152038

Sajadi, MM, Farshidpour, M, Brown, EP, Ouyang, X, Seaman, MS, Pazgier, M, Ackerman, ME, Robinson, H, Tomaras, G, Parsons, MS, Charurat, M, DeVico, AL, Redfield, RR, and Lewis, GK. "Light Chain Bias Associated With Enhanced Binding and Function of Anti-HIV Env Glycoprotein Antibodies." The Journal of infectious diseases 213, no. 1 (January 2016): 156-164.

Zurawski, G, Zurawski, S, Flamar, AL, Richert, L, Wagner, R, Tomaras, GD, Montefiori, DC, Roederer, M, Ferrari, G, Lacabaratz, C, Bonnabau, H, Klucar, P, Wang, Z, Foulds, KE, Kao, SF, Yates, NL, LaBranche, C, Jacobs, BL, Kibler, K, Asbach, B, Kliche, A, Salazar, A, Reed, S, Self, S, Gottardo, R, Galmin, L, Weiss, D, Cristillo, A, Thiebaut, R, Pantaleo, G, and Levy, Y. "Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus Macaques." PloS one 11, no. 4 (January 2016): e0153484