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Affiliate Faculty

Georgia Tomaras

Professor (with tenure), Department of Surgery
Professor, Department of Immunology
Professor, Department of Molecular Genetics and Microbiology
School of Medicine
(919) 681-5598
Georgia Tomaras

Summary

Dr. Tomaras' overall research program is to understand the cellular and humoral immune response to HIV-1 infection and vaccination that are involved in protection from HIV-1. The research in the Tomaras laboratory centers around three main projects involving 1) antiviral CD8 T cell responses in HIV-1 infection and post vaccination, 2) mucosal and systemic antibody responses to infection and vaccination in both non-human primates and humans and 3) the ontogeny of neutralizing antibodies in HIV-1 infection. Her laboratory is also within the Duke Human Vaccine Institute.

Locations

Projects

Recent Publications

Bar-On, Y, Gruell, H, Schoofs, T, Pai, JA, Nogueira, L, Butler, AL, Millard, K, Lehmann, C, Suárez, I, Oliveira, TY, Karagounis, T, Cohen, YZ, Wyen, C, Scholten, S, Handl, L, Belblidia, S, Dizon, JP, Vehreschild, JJ, Witmer-Pack, M, Shimeliovich, I, Jain, K, Fiddike, K, Seaton, KE, Yates, NL, Horowitz, J, Gulick, RM, Pfeifer, N, Tomaras, GD, Seaman, MS, Fätkenheuer, G, Caskey, M, Klein, F, & Nussenzweig, MC. (2018, September 26). Safety and antiviral activity of combination HIV-1 broadly neutralizing antibodies in viremic individuals. Nature Medicine,.
Mendoza, P, Gruell, H, Nogueira, L, Pai, JA, Butler, AL, Millard, K, Lehmann, C, Suárez, I, Oliveira, TY, Lorenzi, JCC, Cohen, YZ, Wyen, C, Kümmerle, T, Karagounis, T, Lu, C-L, Handl, L, Unson-O'Brien, C, Patel, R, Ruping, C, Schlotz, M, Witmer-Pack, M, Shimeliovich, I, Kremer, G, Thomas, E, Seaton, KE, Horowitz, J, West, AP, Bjorkman, PJ, Tomaras, GD, Gulick, RM, Pfeifer, N, Fätkenheuer, G, Seaman, MS, Klein, F, Caskey, M, & Nussenzweig, MC. (2018, September 26). Combination therapy with anti-HIV-1 antibodies maintains viral suppression. Nature, 561 (7724), 479-484.
Singh, S, Ramírez-Salazar, EG, Doueiri, R, Valentin, A, Rosati, M, Hu, X, Keele, BF, Shen, X, Tomaras, GD, Ferrari, G, LaBranche, C, Montefiori, DC, Das, J, Alter, G, Trinh, HV, Hamlin, C, Rao, M, Dayton, F, Bear, J, Chowdhury, B, Alicea, C, Lifson, JD, Broderick, KE, Sardesai, NY, Sivananthan, SJ, Fox, CB, Reed, SG, Venzon, DJ, Hirsch, VM, Pavlakis, GN, & Felber, BK. (2018, August). Control of Heterologous Simian Immunodeficiency Virus SIVsmE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques. Journal of Virology, 92 (15).
Barouch, DH, Tomaka, FL, Wegmann, F, Stieh, DJ, Alter, G, Robb, ML, Michael, NL, Peter, L, Nkolola, JP, Borducchi, EN, Chandrashekar, A, Jetton, D, Stephenson, KE, Li, W, Korber, B, Tomaras, GD, Montefiori, DC, Gray, G, Frahm, N, McElrath, MJ, Baden, L, Johnson, J, Hutter, J, Swann, E, Karita, E, Kibuuka, H, Mpendo, J, Garrett, N, Mngadi, K, Chinyenze, K, Priddy, F, Lazarus, E, Laher, F, Nitayapan, S, Pitisuttithum, P, Bart, S, Campbell, T, Feldman, R, Lucksinger, G, Borremans, C, Callewaert, K, Roten, R, Sadoff, J, Scheppler, L, Weijtens, M, Feddes-de Boer, K, van Manen, D, Vreugdenhil, J, Zahn, R, Lavreys, L, Nijs, S, Tolboom, J, Hendriks, J, Euler, Z, Pau, MG, & Schuitemaker, H. (2018, July 6). Evaluation of a mosaic HIV-1 vaccine in a multicentre, randomised, double-blind, placebo-controlled, phase 1/2a clinical trial (APPROACH) and in rhesus monkeys (NHP 13-19). Lancet (London, England), 392 (10143), 232-243.

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