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Faculty

Chris Woods

Professor, Medicine and Global Health
Director of Graduate Studies, Duke Global Health Institute
Chief, Infectious Diseases Division, Durham VA Medical Center
School of Medicine
Medicine: Infectious Diseases

Trent 205
(919) 668-7174
chris.woods@duke.edu

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Chris Woods

Summary

Dr. Woods is the Co-Director of the Hubert-Yeargan Center for Global Health. He is a professor in the Departments of Medicine and Pathology at Duke University; an adjunct professor in Epidemiology at the University of North Carolina at Chapel Hill School of Public Health; an adjunct professor in the Emerging Infections Program at the Duke-National University of Singapore Graduate Medical School. Clinically, he serves as Chief of Infectious Diseases and clinical microbiology, and hospital epidemiologist for the Durham VA Medical Center. Dr. Woods is board-certified in internal medicine, infectious diseases, and medical microbiology.

Dr. Woods attended Yale University and pursued his medical education and training at Duke University and public health training at UNC-Chapel Hill. He is a graduate of the Epidemic Intelligence Service (EIS) of the Centers for Disease Control and Prevention (CDC), where he served in the Meningitis and Special Pathogens Branch of the National Center for Infectious Diseases. He formulated his interest in global health at Tenwek Hospital in Bomet, Kenya during his internal medicine residency and while at CDC, Dr. Woods performed programmatic work and outbreak investigations throughout the U.S. and the developing world. He currently serves as the Director of Graduate Studies and the MSc for Global Health in the Duke Global Health Institute.

Dr. Woods has published over 130 peer-reviewed articles and has a particular interest in development of medical microbiology capacity in the developing world and the epidemiology of emerging and re-emerging infectious diseases. His research focuses on the development of novel diagnostic approaches to infectious disease and the potential for interspecies transmission of pathogens. His genomic approach to harnessing the host response for diagnosis of infectious diseases has been called a paradigm shift in the field. Dr. Woods is a partner in the Southeastern Center for Emerging Biological Threats, core PI of the Southeastern Research Center for Excellence on Emerging Infections and Biodefense, and a leader in the NIH-funded Vaccine and Therapeutics Evaluation Unit at Duke.

Teaching

Title Number Level Semester Requirements Fulfilled
Global Health Challenges

Course introduces major global health problems and social, behavioral, economic, biomedical and environmental determinants of health in resource limited settings. Topics include communicable diseases i.e. HIV, malaria, tuberculosis and common childhood diseases; chronic diseases such as cancer, diabetes, cardiovascular disease and mental health; and determinants of health associated with these diseases, such as poverty, gender imbalance, culture, poor environmental sanitation, malnutrition, tobacco use, and climate change. Other topics may include health promotion, reproductive health, maternal and child health, and disaster preparedness.

Course Notes:
GLHLTH 701
Was: GLHLTH 310
GRAD Only FALL 2016 MSC: Core
PhD: Core
One Health: From Philosophy to Practice

Interdisciplinary course introducing construct of One Health as increasingly important to a holistic understanding of prevention of disease and maintenance of health. Includes discussion of bidirectional impact of animal health on human health, impact of earth’s changing ecology on health. Learning objectives include 1) to describe how different disciplines contribute to the practice of One Health, 2) to creatively design interdisciplinary interventions to improve Global Health using a One Health model. Course will include weekly 2-hour multi-campus seminar off-site at NC Biotechnology Center with on-campus discussion section using case studies to supplement the seminar.
Interdisciplinary course introducing construct of One Health as increasingly important to a holistic understanding of prevention of disease and maintenance of health. Includes discussion of bidirectional impact of animal health on human health, impact of earth¿s changing ecology on health. Learning objectives include 1) to describe how different disciplines contribute to the practice of One Health, 2) to creatively design interdisciplinary interventions to improve Global Health using a One Health model. Course will include weekly 2-hour multi-campus seminar off-site at NC Biotechnology Center with on-campus discussion section using case studies to supplement the seminar.

Course Notes:
GLHLTH 771
Was: GLHLTH 371
GRAD Only SPRING 2015 MSC: Elective
PhD: Elective
Ungraded Research in Global Health

Individual research in a field of special interest, the central goal of which is a substantive paper containing significant analysis and interpretation of a previously approved topic. Consent required. Individual research in a field of special interest, the central goal of which is a substantive paper containing significant analysis and interpretation of a previously approved topic. Consent required

Course Notes:
GLHLTH 781
Was: GLHLTH 381
GRAD Only SPRING 2015 MSC: Thesis

Projects

Recent Publications

Ebola clinical trials: Five lessons learned and a way forward.nThielman NM, Cunningham CK, Woods C, Petzold E, Sprenz M, Russell J. Clin Trials. 2016 Jan 14. pii: 1740774515619897. [Epub ahead of print] No abstract available. PMID: 26768559.

A response adaptive randomization platform trial for efficient evaluation of Ebola virus treatments: A model for pandemic response.nBerry SM, Petzold EA, Dull P, Thielman NM, Cunningham CK, Corey GR, McClain MT, Hoover DL, Russell J, Griffiss JM, Woods CW.nClin Trials. 2016 Jan 14. pii: 1740774515621721. [Epub ahead of print]nPMID: 26768569

Host gene expression classifiers diagnose acute respiratory illness etiology.nTsalik EL, Henao R, Nichols M, Burke T, Ko ER, McClain MT, Hudson LL, Mazur A, Freeman DH, Veldman T, Langley RJ, Quackenbush EB, Glickman SW, Cairns CB, Jaehne AK, Rivers EP, Otero RM, Zaas AK, Kingsmore SF, Lucas J, Fowler VG Jr, Carin L, Ginsburg GS, Woods CW.nSci Transl Med. 2016 Jan 20;8(322):322ra11. doi: 10.1126/scitranslmed.aad6873.nPMID: 26791949

An individualized predictor of health and disease using paired reference and target samples.nLiu TY, Burke T, Park LP, Woods CW, Zaas AK, Ginsburg GS, Hero AO.nBMC Bioinformatics. 2016 Jan 22;17(1):47. doi: 10.1186/s12859-016-0889-9.nPMID: 26801061

Transcriptomic Analysis of the Host Response and Innate Resilience to Enterotoxigenic Escherichia coli Infection in Humans.nYang WE, Suchindran S, Nicholson BP, McClain MT, Burke T, Ginsburg GS, Harro CD, Chakraborty S, Sack DA, Woods CW, Tsalik EL.nJ Infect Dis. 2016 Jan 18. pii: jiv593. [Epub ahead of print]nPMID: 26787651

Impact of a combined pediatric and adult pneumococcal immunization program on adult pneumonia incidence and mortality in Nicaragua.nBecker-Dreps S, Amaya E, Liu L, Rocha J, Briceño R, Moreno G, Alemán J, Hudgens MG, Woods CW, Weber DJ.nVaccine. 2015 Jan 1;33(1):222-7. doi: 10.1016/j.vaccine.2014.10.073. Epub 2014 Nov 4.nPMID: 25444795

One-year outcome following biological or mechanical valve replacement for infective endocarditis.nDelahaye F, Chu VH, Altclas J, Barsic B, Delahaye A, Freiberger T, Gordon DL, Hannan MM, Hoen B, Kanj SS, Lejko-Zupanc T, Mestres CA, Pachirat O, Pappas P, Lamas C, Selton-Suty C, Tan R, Tattevin P, Wang A; International Collaboration on Endocarditis Prospective Cohort Study (ICE-PCS) Investigators.nInt J Cardiol. 2015 Jan 15;178:117-23. doi: 10.1016/j.ijcard.2014.10.125. Epub 2014 Oct 22.nPMID: 25464234

An under-recognized influenza epidemic identified by rapid influenza testing, southern Sri Lanka, 2013.nTillekeratne LG, Bodinayake CK, Nagahawatte A, Vidanagama D, Devasiri V, Arachchi WK, Kurukulasooriya R, De Silva AD, Østybe T, Reller ME, Woods CW.nAm J Trop Med Hyg. 2015 May;92(5):1023-9. doi: 10.4269/ajtmh.14-0708. Epub 2015 Mar 2.nPMID: 25732679

Etiology of pediatric fever in western Kenya: a case-control study of falciparum malaria, respiratory viruses, and streptococcal pharyngitis.nO'Meara WP, Mott JA, Laktabai J, Wamburu K, Fields B, Armstrong J, Taylor SM, MacIntyre C, Sen R, Menya D, Pan W, Nicholson BP, Woods CW, Holland TL.nAm J Trop Med Hyg. 2015 May;92(5):1030-7. doi: 10.4269/ajtmh.14-0560. Epub 2015 Mar 9.nPMID: 25758648

Renal systems biology of patients with systemic inflammatory response syndrome.nTsalik EL, Willig LK, Rice BJ, van Velkinburgh JC, Mohney RP, McDunn JE, Dinwiddie DL, Miller NA, Mayer ES, Glickman SW, Jaehne AK, Glew RH, Sopori ML, Otero RM, Harrod KS, Cairns CB, Fowler VG, Rivers EP, Woods CW, Kingsmore SF, Langley RJ.nKidney Int. 2

Clinical MRSA isolates from skin and soft tissue infections show increased in vitro production of phenol soluble modulins.nBerlon NR, Qi R, Sharma-Kuinkel BK, Joo HS, Park LP, George D, Thaden JT, Messina JA, Maskarinec SA, Mueller-Premru M, Athan E, Tattevin P, Pericas JM, Woods CW, Otto M, Fowler VG Jr.nJ Infect. 2015 Oct;71(4):447-57. doi: 10.1016/j.jinf.2015.06.005. Epub 2015 Jun 14.nPMID: 26079275

What was old is new again: using the host response to diagnose infectious disease.nKo ER, Yang WE, McClain MT, Woods CW, Ginsburg GS, Tsalik EL.nExpert Rev Mol Diagn. 2015;15(9):1143-58. doi: 10.1586/14737159.2015.1059278. Epub 2015 Jul 4.nPMID: 26145249

Gene Expression Profiles Link Respiratory Viral Infection, Platelet Response to Aspirin, and Acute Myocardial Infarction.nRose JJ, Voora D, Cyr DD, Lucas JE, Zaas AK, Woods CW, Newby LK, Kraus WE, Ginsburg GS.nPLoS One. 2015 Jul 20;10(7):e0132259. doi: 10.1371/journal.pone.0132259. eCollection 2015.nPMID: 26193668

Use of Rapid Influenza Testing to Reduce Antibiotic Prescriptions Among Outpatients with Influenza-Like Illness in Southern Sri Lanka.nTillekeratne LG, Bodinayake CK, Nagahawatte A, Vidanagama D, Devasiri V, Arachchi WK, Kurukulasooriya R, De Silva AD, Østbye T, Reller ME, Woods CW.nAm J Trop Med Hyg. 2015 Nov 4;93(5):1031-7. doi: 10.4269/ajtmh.15-0269. Epub 2015 Aug 17.nPMID: 26283748

Pneumococcal Carriage and Vaccine Coverage in Retirement Community Residents.nBecker-Dreps S, Kistler CE, Ward K, Killeya-Jones LA, Better OM, Weber DJ, Zimmerman S, Nicholson BP, Woods CW, Sloane P.nJ Am Geriatr Soc. 2015 Oct;63(10):2094-8. doi: 10.1111/jgs.13651. Epub 2015 Oct 12.nPMID: 26456473

Differential evolution of peripheral cytokine levels in symptomatic and asymptomatic responses to experimental influenza virus challenge.nMcClain MT, Henao R, Williams J, Nicholson B, Veldman T, Hudson L, Tsalik EL, Lambkin-Williams R, Gilbert A, Mann A, Ginsburg GS, Woods CW.nClin Exp Immunol. 2015 Oct 28. doi: 10.1111/cei.12736. [Epub ahead of print]nPMID: 26506932

Potential Cost-effectiveness of Early Identification of Hospital-acquired Infection in Critically Ill Patients.nTsalik EL, Li Y, Hudson LL, Chu VH, Himmel T, Limkakeng AT, Katz JN, Glickman SW, McClain MT, Welty-Wolf KE, Fowler VG, Ginsburg GS, Woods CW, Reed SD.nAnn Am Thorac Soc. 2015 Dec 23. [Epub ahead of print]nPMID: 26700878

Kutty PK, Woods CW, Sena AC, Benoit SR, Naggie S, Frederick J, Evans S, Engel J, McDonald LC. Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA. Emerg Infect Dis. 2010 Feb;16(2):197-204.

An integrated transcriptome and expressed variant analysis of sepsis survival and death.nTsalik EL, Langley RJ, Dinwiddie DL, Miller NA, Yoo B, van Velkinburgh JC, Smith LD, Thiffault I, Jaehne AK, Valente AM, Henao R, Yuan X, Glickman SW, Rice BJ, McClain MT, Carin L, Corey GR, Ginsburg GS, Cairns CB, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF. Genome Med. 2014 Nov 26;6(11):111. doi: 10.1186/s13073-014-0111-5. eCollection 2014. PMID: 25538794.

High-Dimensional Longitudinal Genomic Data: An analysis used for monitoring viral infections.nCarin L, Hero A 3rd, Lucas J, Dunson D, Chen M, Heñao R, Tibau-Puig A, Zaas A, Woods CW, Ginsburg GS. IEEE Signal Process Mag. 2012 Jan 1;29(1):108-123. No abstract available. PMID: 24678238.

Unsuspected dengue and acute febrile illness in rural and semi-urban southern Sri Lanka. Reller ME, Bodinayake C, Nagahawatte A, Devasiri V, Kodikara-Arachichi W, Strouse JJ, Broadwater A, Østbye T, de Silva A, Woods CW. Emerg Infect Dis. 2012 Feb;18(2):256-63. doi: 10.3201/eid1802.110962.nPMID: 22304972.

Unsuspected rickettsioses among patients with acute febrile illness, Sri Lanka, 2007. Reller ME, Bodinayake C, Nagahawatte A, Devasiri V, Kodikara-Arachichi W, Strouse JJ, Flom JE, Østbye T, Woods CW, Dumler JS.nEmerg Infect Dis. 2012 May;18(5):825-9. doi: 10.3201/eid1805.111563.nPMID: 22516455.

Automated detection of influenza-like illness using clinical surveillance markers at a Department of Veterans Affairs Medical Center. Park LP, Rao S, Nabity SA, Abbott D, Frederick J, Woods CW. Emerg Health Threats J. 2011 Apr 20;4:7108. doi: 10.3402/ehtj.v4i0.7108.nPMID: 24149026.

A case-control study of community-associated Clostridium difficile infection: no role for proton pump inhibitors. Naggie S, Miller BA, Zuzak KB, Pence BW, Mayo AJ, Nicholson BP, Kutty PK, McDonald LC, Woods CW. Am J Med. 2011 Mar;124(3):276.e1-7. doi: 10.1016/j.amjmed.2010.10.013.nPMID: 21396512.

An Infection Control Program for a 2009 influenza A H1N1 outbreak in a university-based summer camp.nTsalik EL, Cunningham CK, Cunningham HM, Lopez-Marti MG, Sangvai DG, Purdy WK, Anderson DJ, Thompson JR, Brown M, Woods CW, Jaggers LB, Hendershot EF.nJ Am Coll Health. 2011;59(5):419-26. doi: 10.1080/07448481.2010.534215.nPMID: 21500062.

Hallucinations, sensory neuropathy, and peripheral visual deficits in a young woman infected with Bartonella koehlerae. Breitschwerdt EB, Mascarelli PE, Schweickert LA, Maggi RG, Hegarty BC, Bradley JM, Woods CW. J Clin Microbiol. 2011 Sep;49(9):3415-7. doi: 10.1128/JCM.00833-11. Epub 2011 Jul 6. PMID: 21734026.

Methicillin-susceptible Staphylococcus aureus endocarditis isolates are associated with clonal complex 30 genotype and a distinct repertoire of enterotoxins and adhesins. Nienaber JJ, Sharma Kuinkel BK, Clarke-Pearson M, Lamlertthon S, Park L, Rude TH, Barriere S, Woods CW, Chu VH, Marín M, Bukovski S, Garcia P, Corey GR, Korman T, Doco-Lecompte T, Murdoch DR, Reller LB, Fowler VG Jr; International Collaboration on Endocarditis-Microbiology Investigators. J Infect Dis. 2011 Sep 1;204(5):704-13. doi: 10.1093/infdis/jir389. Erratum in: J Infect Dis. 2013 Feb 1;207(3):546. PMID: 21844296.

Leptospirosis as frequent cause of acute febrile illness in southern Sri Lanka. Reller ME, Bodinayake C, Nagahawatte A, Devasiri V, Kodikara-Arachichi W, Strouse JJ, Flom JE, Dumler JS, Woods CW.nEmerg Infect Dis. 2011 Sep;17(9):1678-84. doi: 10.3201/eid1709.100915.nPMID: 21888794.

Temporal dynamics of host molecular responses differentiate symptomatic and asymptomatic influenza a infection.nHuang Y, Zaas AK, Rao A, Dobigeon N, Woolf PJ, Veldman T, Øien NC, McClain MT, Varkey JB, Nicholson B, Carin L, Kingsmore S, Woods CW, Ginsburg GS, Hero AO 3rd.nPLoS Genet. 2011 Aug;7(8):e1002234. doi: 10.1371/journal.pgen.1002234. Epub 2011 Aug 25.nPMID: 21901105.

H3N2 influenza infection elicits more cross-reactive and less clonally expanded anti-hemagglutinin antibodies than influenza vaccination.nMoody MA, Zhang R, Walter EB, Woods CW, Ginsburg GS, McClain MT, Denny TN, Chen X, Munshaw S, Marshall DJ, Whitesides JF, Drinker MS, Amos JD, Gurley TC, Eudailey JA, Foulger A, DeRosa KR, Parks R, Meyerhoff RR, Yu JS, Kozink DM, Barefoot BE, Ramsburg EA, Khurana S, Golding H, Vandergrift NA, Alam SM, Tomaras GD, Kepler TB, Kelsoe G, Liao HX, Haynes BF.nPLoS One. 2011;6(10):e25797. doi: 10.1371/journal.pone. 0025797. Epub 2011 Oct 19.nPMID: 22039424.

Discriminative value of inflammatory biomarkers for suspected sepsis.nTsalik EL, Jaggers LB, Glickman SW, Langley RJ, van Velkinburgh JC, Park LP, Fowler VG, Cairns CB, Kingsmore SF, Woods CW. J Emerg Med. 2012 Jul;43(1):97-106. doi: 10.1016/j.jemermed.2011.05.072. Epub 2011 Nov 6. PMID: 22056545.

Performance of diagnostic tests to detect respiratory viruses in older adults. She RC, Polage CR, Caram LB, Taggart EW, Hymas WC, Woods CW, Schmader K, Petti CA. Diagn Microbiol Infect Dis. 2010 Jul;67(3):246-50. doi:10.1016/j.diagmicrobio.2010.02.020. PMID: 20542205.

Community-associated Clostridium difficile infection: experience of a veteran affairs medical center in southeastern USA. Naggie S, Frederick J, Pien BC, Miller BA, Provenzale DT, Goldberg KC, Woods CW. Infection. 2010 Aug;38(4):297-300. doi: 10.1007/s15010-010-0025-0. Epub 2010 May 8. PMID: 20454827.

Bartonella vinsonii subsp. berkhoffii and Bartonella henselae bacteremia in a father and daughter with neurological disease. Breitschwerdt EB, Maggi RG, Lantos PM, Woods CW, Hegarty BC, Bradley JM.nParasit Vectors. 2010 Apr 8;3(1):29. doi:10.1186/1756-3305-3-29.nPMID: 20377863.

Disease progression in hemodynamically stable patients presenting to the emergency department with sepsis.nGlickman SW, Cairns CB, Otero RM, Woods CW, Tsalik EL, Langley RJ, van Velkinburgh JC, Park LP, Glickman LT, Fowler VG Jr, Kingsmore SF, Rivers EP.nAcad Emerg Med. 2010 Apr;17(4):383-90. doi: 10.1111/j.1553-2712.2010.00664.x.PMID: 20370777.

Multicenter evaluation of the LightCycler methicillin-resistant Staphylococcus aureus (MRSA) advanced test as a rapid method for detection of MRSA in nasal surveillance swabs. Peterson LR, Liesenfeld O, Woods CW, Allen SD, Pombo D, Patel PA, Mehta MS, Nicholson B, Fuller D, Onderdonk A. J Clin Microbiol. 2010 May;48(5):1661-6. doi: 10.1128/JCM.00003-10. Epub 2010 Mar 24. PMID: 20335423.

Risk factors for and estimated incidence of community-associated Clostridium difficile infection, North Carolina, USA. Kutty PK, Woods CW, Sena AC, Benoit SR, Naggie S, Frederick J, Evans S, Engel J, McDonald LC. Emerg Infect Dis. 2010 Feb;16(2):197-204. doi: 10.3201/eid1602.090953. PMID: 20113547.

Clinical presentation and response to treatment of novel influenza A H1N1 in a university-based summer camp population. Tsalik EL, Hendershot EF, Sangvai DG, Cunningham HM, Cunningham CK, Lopez-Marti MG, Purdy WK, Woods CW, Caram LB. J Clin Virol. 2010 Mar;47(3):286-8. doi: 10.1016/j.jcv.2009.12.012. Epub 2010 Jan 12. PMID: 20064740.

Multiplex PCR to diagnose bloodstream infections in patients admitted from the emergency department with sepsis. Tsalik EL, Jones D, Nicholson B, Waring L, Liesenfeld O, Park LP, Glickman SW, Caram LB, Langley RJ, van Velkinburgh JC, Cairns CB, Rivers EP, Otero RM, Kingsmore SF, Lalani T, Fowler VG, Woods CW.nJ Clin Microbiol. 2010 Jan;48(1):26-33. doi: 10.1128/JCM.01447-09. Epub 2009 Oct 21. PMID: 19846634.

Detection of viruses via statistical gene expression analysis.nChen M, Carlson D, Zaas A, Woods CW, Ginsburg GS, Hero A 3rd, Lucas J, Carin L. IEEE Trans Biomed Eng. 2011 Mar;58(3):468-79. doi: 10.1109/TBME.2010.2059702. Epub 2010 Jul 19. PMID: 20643599.

Tenover FC, Novak-Weekley S, Woods CW, Peterson LR, Davis T, Schreckenberger P, Fang FC, Dascal A, Gerding DN, Nomura JH, Goering RV, Akerlund T, Weissfeld AS, Baron EJ, Wong E, Marlowe EM, Whitmore J, Persing DH. Impact of Strain Types on Detection of Toxigenic Clostridium difficile: Comparison of Molecular Diagnostic and Enzyme Immunoassay Approaches. J Clin Microbiol. 2010 Aug 11.

Pien BC, Sundaram P, Raoof N, Costa SF, Mirrett S, Woods CW, Reller LB, Weinstein MP. The The clinical and prognostic importance of positive blood cultures in adults. Am J Med. 2010 Sep;123(9):819-28.

She-Bender R, Caram LB, Polage C, Woods CW, Petti C. Performance of diagnostic tests to detect respiratory viruses in older adults. Diagn Microbiol Infect Dis. 2010 Jul;67(3):246-50.

Oliveira AM, Maggi RG, Woods CW, Breitschwerdt EB. Suspected Needle Stick Transmission of Bartonella vinsonii subspecies berkhoffii to a Veterinarian.J Vet Intern Med. 2010 Jul 28.

Naggie S, Frederick J, Pien BC, Miller BA, Provenzale DT, Goldberg KC, Woods CW. Community-associated Clostridium difficile infection: experience of a veteran affairs medical center in southeastern USA. Infection. 2010 May 8. (Epub ahead of print)

Glickman SW, Tsalik EL, Cairns CB, Otero RM, Woods CW, Langley RJ, van Velkinburgh JC, Fowler VG, Glickman LT, Kingsmore SF, Rivers EP. Disease progression in hemodynamically stable patients presenting to the emergency department with sepsis. Academic Emergency Medicine 2010 Apr;17(4):383-90.

Shao HJ, Crump JA, Ramadhani HO, Uiso LO, Ole-Nguyaine S, Moon AM, Kiwera RA, Woods CW, Shao JF, Bartlett JA, Thielman NM. Early versus delayed fixed dose combination abacavir/lamivudine/zidovudine in patients with HIV and tuberculosis in Tanzania. AIDS Res Hum Retroviruses. 2009 Dec;25(12):1277-85.

Clinical characteristics and outcome of infective endocarditis involving implantable cardiac devices.nAthan E, Chu VH, Tattevin P, Selton-Suty C, Jones P, Naber C, Miró JM, Ninot S, Fernández-Hidalgo N, Durante-Mangoni E, Spelman D, Hoen B, Lejko-Zupanc T, Cecchi E, Thuny F, Hannan MM, Pappas P, Henry M, Fowler VG Jr, Crowley AL, Wang A; ICE-PCS Investigators.nJAMA. 2012 Apr 25;307(16):1727-35. doi: 10.1001/jama.2012.497.nPMID: 22535857.

Phase 2 assessment of the safety and immunogenicity of two inactivated pandemic monovalent H1N1 vaccines in adults as a component of the U.S. pandemic preparedness plan in 2009. Chen WH, Winokur PL, Edwards KM, Jackson LA, Wald A, Walter EB, Noah DL, Wolff M, Kotloff KL; Pandemic H1N1 Vaccine Adult Study Group.nVaccine. 2012 Jun 13;30(28):4240-8. doi: 10.1016/j.vaccine.2012.04.044. Epub 2012 Apr 23. PMID: 22537984.

Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke.nBarsic B, Dickerman S, Krajinovic V, Pappas P, Altclas J, Carosi G, Casabé JH, Chu VH, Delahaye F, Edathodu J, Fortes CQ, Olaison L, Pangercic A, Patel M, Rudez I, Tamin SS, Vincelj J, Bayer AS, Wang A; International Collaboration on Endocarditis - Prospective Cohort Study Investigators. Clin Infect Dis. 2013 Jan;56(2):209-17. doi: 10.1093/cid/cis878. Epub 2012 Oct 16. PMID: 23074311.

Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.nAhn SH, Tsalik EL, Cyr DD, Zhang Y, van Velkinburgh JC, Langley RJ, Glickman SW, Cairns CB, Zaas AK, Rivers EP, Otero RM, Veldman T, Kingsmore SF, Lucas J, Woods CW, Ginsburg GS, Fowler VG Jr. PLoS One. 2013;8(1):e48979. doi: 10.1371/journal.pone.0048979. Epub 2013 Jan 9. PMID: 23326304.

A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.nWoods CW, McClain MT, Chen M, Zaas AK, Nicholson BP, Varkey J, Veldman T, Kingsmore SF, Huang Y, Lambkin-Williams R, Gilbert AG, Hero AO 3rd, Ramsburg E, Glickman S, Lucas JE, Carin L, Ginsburg GS. PLoS One. 2013;8(1):e52198. doi: 10.1371/journal.pone.0052198. Epub 2013 Jan 9. PMID: 23326326.

Enterococcal endocarditis in the beginning of the 21st century: analysis from the International Collaboration on Endocarditis-Prospective Cohort Study.nChirouze C, Athan E, Alla F, Chu VH, Ralph Corey G, Selton-Suty C, Erpelding ML, Miro JM, Olaison L, Hoen B; International Collaboration on Endocarditis Study Group. Clin Microbiol Infect. 2013 Dec;19(12):1140-7. doi: 10.1111/1469-0691.12166. Epub 2013 Mar 20. PMID: 23517406.

HACEK infective endocarditis: characteristics and outcomes from a large, multi-national cohort. Chambers ST, Murdoch D, Morris A, Holland D, Pappas P, Almela M, Fernández-Hidalgo N, Almirante B, Bouza E, Forno D, del Rio A, Hannan MM, Harkness J, Kanafani ZA, Lalani T, Lang S, Raymond N, Read K, Vinogradova T, Woods CW, Wray D, Corey GR, Chu VH; International Collaboration on Endocarditis Prospective Cohort Study Investigators. PLoS One. 2013 May 17;8(5):e63181. doi: 10.1371/journal.pone.0063181. Print 2013. PMID: 23690995.

Comparing influenza and RSV viral and disease dynamics in experimentally infected adults predicts clinical effectiveness of RSV antivirals. Bagga B, Woods CW, Veldman TH, Gilbert A, Mann A, Balaratnam G, Lambkin-Williams R, Oxford JS, McClain MT, Wilkinson T, Nicholson BP, Ginsburg GS, Devincenzo JP.nAntivir Ther. 2013;18(6):785-91. doi: 10.3851/IMP2629. Epub 2013 May 28. PMID: 23714753.

Surface-enhanced Raman scattering molecular sentinel nanoprobes for viral infection diagnostics. Wang HN, Fales AM, Zaas AK, Woods CW, Burke T, Ginsburg GS, Vo-Dinh T.nAnal Chim Acta. 2013 Jul 5;786:153-8. doi: 10.1016/j.aca.2013.05.017. Epub 2013 May 20. PMID: 23790305.

In-hospital and 1-year mortality in patients undergoing early surgery for prosthetic valve endocarditis. Lalani T, Chu VH, Park LP, Cecchi E, Corey GR, Durante-Mangoni E, Fowler VG Jr, Gordon D, Grossi P, Hannan M, Hoen B, Muñoz P, Rizk H, Kanj SS, Selton-Suty C, Sexton DJ, Spelman D, Ravasio V, Tripodi MF, Wang A; International Collaboration on Endocarditis - Prospective Cohort Study Investigators. JAMA Intern Med. 2013 Sep 9;173(16):1495-504. doi: 10.1001/jamainternmed.2013.8203. Erratum in: JAMA Intern Med. 2013 Oct 28;173(19):1846. PMID: 23857547.

An integrated clinico-metabolomic model improves prediction of death in sepsis.nLangley RJ, Tsalik EL, van Velkinburgh JC, Glickman SW, Rice BJ, Wang C, Chen B, Carin L, Suarez A, Mohney RP, Freeman DH, Wang M, You J, Wulff J, Thompson JW, Moseley MA, Reisinger S, Edmonds BT, Grinnell B, Nelson DR, Dinwiddie DL, Miller NA, Saunders CJ, Soden SS, Rogers AJ, Gazourian L, Fredenburgh LE, Massaro AF, Baron RM, Choi AM, Corey GR, Ginsburg GS, Cairns CB, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF.nSci Transl Med. 2013 Jul 24;5(195):195ra95. doi: 10.1126/scitranslmed.3005893.nPMID: 23884467.

Plasma microRNA signature as a noninvasive biomarker for acute graft-versus-host disease.nXiao B, Wang Y, Li W, Baker M, Guo J, Corbet K, Tsalik EL, Li QJ, Palmer SM, Woods CW, Li Z, Chao NJ, He YW. Blood. 2013 Nov 7;122(19):3365-75. doi: 10.1182/blood-2013-06-510586. Epub 2013 Sep 16. PMID: 24041574.

A host-based RT-PCR gene expression signature to identify acute respiratory viral infection.nZaas AK, Burke T, Chen M, McClain M, Nicholson B, Veldman T, Tsalik EL, Fowler V, Rivers EP, Otero R, Kingsmore SF, Voora D, Lucas J, Hero AO, Carin L, Woods CW, Ginsburg GS.nSci Transl Med. 2013 Sep 18;5(203):203ra126. doi: 10.1126/scitranslmed.3006280.nPMID: 24048524

Quantitative models of the dose-response and time course of inhalational anthrax in humans.nToth DJ, Gundlapalli AV, Schell WA, Bulmahn K, Walton TE, Woods CW, Coghill C, Gallegos F, Samore MH, Adler FR. PLoS Pathog. 2013 Aug;9(8):e1003555. doi: 10.1371/journal.ppat.1003555. Epub 2013 Aug 15. PMID: 24058320.

Repeat endocarditis: analysis of risk factors based on the International Collaboration on Endocarditis - Prospective Cohort Study. Alagna L, Park LP, Nicholson BP, Keiger AJ, Strahilevitz J, Morris A, Wray D, Gordon D, Delahaye F, Edathodu J, Miró JM, Fernández-Hidalgo N, Nacinovich FM, Shahid R, Woods CW, Joyce MJ, Sexton DJ, Chu VH. Clin Microbiol Infect. 2014 Jun;20(6):566-75. doi: 10.1111/1469-0691.12395. Epub 2013 Nov 11. PMID: 24102907.

Longitudinal analysis of leukocyte differentials in peripheral blood of patients with acute respiratory viral infections. McClain MT, Park LP, Nicholson B, Veldman T, Zaas AK, Turner R, Lambkin-Williams R, Gilbert AS, Ginsburg GS, Woods CW.nJ Clin Virol. 2013 Dec;58(4):689-95. doi: 10.1016/j.jcv.2013.09.015. Epub 2013 Sep 28. PMID: 24140015.

Chikungunya as a cause of acute febrile illness in southern Sri Lanka.nReller ME, Akoroda U, Nagahawatte A, Devasiri V, Kodikaarachchi W, Strouse JJ, Chua R, Hou Y, Chow A, Sessions OM, Østbye T, Gubler DJ, Woods CW, Bodinayake C.nPLoS One. 2013 Dec 2;8(12):e82259. doi: 10.1371/journal.pone.0082259. eCollection 2013. PMID: 24312651.

Widespread dissemination of CTX-M-15 genotype extended-spectrum-%u03B2-lactamase-producing enterobacteriaceae among patients presenting to community hospitals in the southeastern United States.nChen LF, Freeman JT, Nicholson B, Keiger A, Lancaster S, Joyce M, Woods CW, Cook E, Adcock L, Louis S, Cromer AL, Sexton DJ, Anderson DJ. Antimicrob Agents Chemother. 2014;58(2):1200-2. doi: 10.1128/AAC.01099-13. Epub 2013 Nov 18. PMID: 24247126.

Spontaneous onset of complex regional pain syndrome Type I in a woman infected with Bartonella koehlerae. Vera CP, Maggi RG, Woods CW, Mascarelli PE, Breitschwerdt EB. Med Microbiol Immunol. 2014 Apr;203(2):101-7. doi: 10.1007/s00430-013-0320-3. Epub 2013 Dec 10. PMID: 24323298.

Development of a novel preclinical model of pneumococcal pneumonia in nonhuman primates.nKraft BD, Piantadosi CA, Benjamin AM, Lucas JE, Zaas AK, Betancourt-Quiroz M, Woods CW, Chang AL, Roggli VL, Marshall CD, Ginsburg GS, Welty-Wolf K. Am J Respir Cell Mol Biol. 2014 May;50(5):995-1004. doi: 10.1165/rcmb.2013-0340OC. PMID: 24328793.

Changes in childhood pneumonia and infant mortality rates following introduction of the 13-valent pneumococcal conjugate vaccine in Nicaragua. Becker-Dreps S, Amaya E, Liu L, Moreno G, Rocha J, Briceño R, Alemán J, Hudgens MG, Woods CW, Weber DJ. Pediatr Infect Dis J. 2014 Jun;33(6):637-42. doi: 10.1097/INF.0000000000000269. PMID: 24445827.

Metabolomic derangements are associated with mortality in critically ill adult patients.nRogers AJ, McGeachie M, Baron RM, Gazourian L, Haspel JA, Nakahira K, Fredenburgh LE, Hunninghake GM, Raby BA, Matthay MA, Otero RM, Fowler VG, Rivers EP, Woods CW, Kingsmore S, Langley RJ, Choi AM. PLoS One. 2014 Jan 30;9(1):e87538. doi: 10.1371/journal.pone.0087538. eCollection 2014. PMID: 24498130.

A novel diagnostic approach may reduce inappropriate antibiotic use for acute respiratory infections.nHudson LL, Woods CW, Ginsburg GS.nExpert Rev Anti Infect Ther. 2014 Mar;12(3):279-82. doi: 10.1586/14787210.2014.881717. Epub 2014 Feb 6. PMID: 24502765.

Reconstructing a B-Cell Clonal Lineage. II. Mutation, Selection, and Affinity Maturation.nKepler TB, Munshaw S, Wiehe K, Zhang R, Yu JS, Woods CW, Denny TN, Tomaras GD, Alam SM, Moody MA, Kelsoe G, Liao HX, Haynes BF.nFront Immunol. 2014 Apr 22;5:170. doi: 10.3389/fimmu.2014.00170. eCollection 2014. PMID: 24795717.

Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. Yan Q, Sharma-Kuinkel BK, Deshmukh H, Tsalik EL, Cyr DD, Lucas J, Woods CW, Scott WK, Sempowski GD, Thaden JT, Rude TH, Ahn SH, Fowler VG Jr.nPLoS Pathog. 2014 Jun 5;10(6):e1004149. doi: 10.1371/journal.ppat.1004149. eCollection 2014 Jun. Erratum in: PLoS Pathog. 2014 Jun;10(6):e1004259. Thaden, Joshua [corrected to Thaden, Joshua T]. PMID: 24901344.

Integrative "omic" analysis of experimental bacteremia identifies a metabolic signature that distinguishes human sepsis from systemic inflammatory response syndromes. Langley RJ, Tipper JL, Bruse S, Baron RM, Tsalik EL, Huntley J, Rogers AJ, Jaramillo RJ, O'Donnell D, Mega WM, Keaton M, Kensicki E, Gazourian L, Fredenburgh LE, Massaro AF, Otero RM, Fowler VG Jr, Rivers EP, Woods CW, Kingsmore SF, Sopori ML, Perrella MA, Choi AM, Harrod KS. Am J Respir Crit Care Med. 2014 Aug 15;190(4):445-55. doi: 10.1164/rccm.201404-0624OC.nPMID: 25054455.

Unsuspected leptospirosis is a cause of acute febrile illness in Nicaragua. Reller ME, Wunder EA Jr, Miles JJ, Flom JE, Mayorga O, Woods CW, Ko AI, Dumler JS, Matute AJ. PLoS Negl Trop Dis. 2014 Jul 24;8(7):e2941. doi: 10.1371/journal.pntd.0002941. eCollection 2014 Jul. PMID: 25058149.

Detection of Bartonella species in the blood of veterinarians and veterinary technicians: a newly recognized occupational hazard?nLantos PM, Maggi RG, Ferguson B, Varkey J, Park LP, Breitschwerdt EB, Woods CW. Vector Borne Zoonotic Dis. 2014 Aug;14(8):563-70. doi: 10.1089/vbz.2013.1512. PMID: 25072986.

The current epidemiology and clinical decisions surrounding acute respiratory infections. Zaas AK, Garner BH, Tsalik EL, Burke T, Woods CW, Ginsburg GS. Trends Mol Med. 2014 Oct;20(10):579-88. doi: 10.1016/j.molmed.2014.08.001. Epub 2014 Sep 5. Review. PMID: 25201713.

DNA bioassay-on-chip using SERS detection for dengue diagnosis.nNgo HT, Wang HN, Fales AM, Nicholson BP, Woods CW, Vo-Dinh T.nAnalyst. 2014 Nov 21;139(22): 5655-9. doi: 10.1039/c4an01077a. PMID: 25248522.

Immunogenicity of avian influenza A/Anhui/01/2005(H5N1) vaccine with MF59 adjuvant: a randomized clinical trial.nBelshe RB, Frey SE, Graham IL, Anderson EL, Jackson LA, Spearman P, Edupuganti S, Mulligan MJ, Rouphael N, Winokur P, Dolor RJ, Woods CW, Walter EB, Chen WH, Turley C, Edwards KM, Creech CB, Hill H, Bellamy AR; National Institute of Allergy and Infectious Diseases - Funded Vaccine and Treatment Evaluation Units. JAMA. 2014 Oct 8;312(14):1420-8. doi: 10.1001/jama.2014.12609. PMID: 25291578.

Impact of early valve surgery on outcome of Staphylococcus aureus prosthetic valve infective endocarditis: analysis in the International Collaboration of Endocarditis-Prospective Cohort Study. Chirouze C, Alla F, Fowler VG Jr, Sexton DJ, Corey GR, Chu VH, Wang A, Erpelding ML, Durante-Mangoni E, Fernández-Hidalgo N, Giannitsioti E, Hannan MM, Lejko-Zupanc T, Miró JM, Muñoz P, Murdoch DR, Tattevin P, Tribouilloy C, Hoen B; ICE Prospective Investigators.nClin Infect Dis. 2015 Mar 1;60(5):741-9. doi: 10.1093/cid/ciu871. Epub 2014 Nov 10. PMID: 25389255.

Breitschwerdt EB, Maggi RB, Lantos PL, Woods CW, Hegarty HC, Bradley JM. Bartonella vinsonii subsp. berkhoffii and Bartonella henselae bacteremia in a father and daughter with neurological disease. Parasites & Vectors 2010, 3:29

Peterson LR, Liesenfeld O, Woods CW, Allen SD, Pombo D, Patel PA, Mehta MS, Nicholson B, Fuller D, Onderdonk A. Multicenter Evaluation of the LightCycler(R) MRSA Advanced Test as a Rapid Method for Detection of Methicillin-resistant Staphylococcus aureus (MRSA) in Nasal Surveillance Swabs.. J Clin Microbiol. 2010 May;48(5):1661-6. Epub 2010 Mar 24.

Tsalik EL, Hendershot EF, Sangvai DG, Cunningham HM, Cunningham CK, Lopez-Marti MG, Purdy WK, Woods CW, Caram LB. Clinical presentation and response to treatment of novel influenza A H1N1 in a university-based summer camp population. J Clin Virol. 2010 Mar;47(3):286-8. Epub 2010 Jan 12.