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Jim Zhang

Professor, Global and Environmental Health
Nicholas School of the Environment

(919) 681-7782

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Jim Zhang


Dr. Zhang joined the Duke Faculty in fall 2013 from the University of Southern California where he had been a professor of environmental and global health and the director of Environmental and Biomarkers Analysis Laboratory since 2010. His prior positions include professor, department chair, and associate dean at the Rutgers School of Public Health. Dr. Zhang has more than 140 peer-reviewed publications. His work has been featured in major international media such as the Time, the New York Times, BBC, ABC, CBS, Yahoo News, etc. His early work on characterizing sources of non-methane greenhouse gases made him one of the officially recognized contributor to the 2007 Nobel Peace Prize awarded to IPCC. He is the 2012 recipient of the Jeremy Wesolowski Award, the highest award of the International Society of Exposure Science. He also received a Distinguished Alumni Award from the Rutgers Graduate School.

Dr. Zhang's research interests include developing novel biomarkers of human exposure and health effects, assessing health and climate co-benefits of air pollution interventions, and examining biological mechanisms by which environmental exposures exert adverse health effects. Dr. Zhang has led a number of international collaborations to study air pollution health effects and underlying pathophysiologic mechanisms. He is currently leading two multidisciplinary, multi-institutional centers studying the health impact of engineered nanomaterials.


Title Number Level Semester Requirements Fulfilled
Air Quality: Human Exposure and Health Effects
Crosslisted as GLHLTH 634

nLooks at how individuals and populations are exposed to air pollution and what adverse health effects the exposure will cause. Covers exposure analysis methods, toxicological and epidemiological studies that examine health effects of air pollution exposure. Students will be prepared to understand concept and major methodologies of analysis for air pollution; how toxicology is used to determine adverse effects of air pollution exposure and underlying biological mechanisms; collect evidence on air pollution health effects in supporting health risk assessment. Prerequisites: general biology, statistics. Instructor: Zhang

Course Notes:
Was: ENVIRON 4692
UG/GRAD FALL 2017 MAJOR: Focused Study
MINOR: Elective
MSC: Elective
PhD: Elective
Air Pollution: From Sources to Health Effects

nBoth urban outdoor air pollution and household indoor air pollution contribute significantly to global burden of disease. Course covers fundamentals about how major air pollutants are generated and transported in the atmosphere and how these pollutants affect human health. Relevant exposure assessment, toxicology and epidemiology case studies are discussed. Prerequisites: general chemistry; introductory-level statistics.

Course Notes:
UG/GRAD SPRING 2014 MSC: Elective


Recent Publications

Dwaipayan, M., Royce, S.G., Sarkar, S., Thorley, A., Schwander S., Ryan, M.P, Porter, A.E., Chung, K.F., Tetley, T.D., Zhang, J., Georgopoulos, P.G., Modeling In Vitro Cellular Reponses to Silver Nanoparticles.J Toxicology. Vol. 2014, ID852890, 13pgs, 2014. DOI:10.1155/2014/852890 View

Mukherjee D., Leo B.F., Royce S.F., Porter A.E., Ryan, M.P., Schwander S., Chung K.F., Tetley, T.D., Zhang, J., Georgopoulos, P.G. Modeling physiochemical interactionsaffecting in vitro cellular dosimetry of engineered nanomaterials: application to nanosilver.J Nanopart Res. DOI 10.1007/s1101-014-2616-7.2014. View

Mu L., Deng, F., Tian L., Swanson, M., Ying, J., Browne, R.W., Rittenhouse-Olson, K., Zhang J., Zhang, Z.F., Bonner, M.R. Peak expiratory flow, breath rate and blood pressure in adults with changes in particulate matter air pollution during the Beijing Olympics: a panel study. Environ Res. DOI: 10.1016/j.envres.2014.05.006. 2014. View

Neophytou A.M., Hart J.E., Yan C., Zhang, J., Smith T. J., Garshick E., Laden F., Short-Term Traffic-Related Exposures and Biomarkers of Nitro-PAH Exposure and Oxidative DNA Damage. Toxics. DOI: 10.3390/20x000x. 2014. View

Variability in Bioreactivity Linked to Changes in Size and Zeta Potential of Diesel Exhaust Particles in Human Immune CellsSarkar S, Zhang L, Subramaniam P, Lee K-B, Garfunkel E, et al. (2014) Variability in Bioreactivity Linked to Changes in Size and Zeta Potential of Diesel Exhaust Particles in Human Immune Cells. PLoS ONE 9(5): e97304. doi: 10.1371/journal.pone.0097304 View

Yuan Z., Chen Y., Zhang Y., Liu Q., Zhao J., Hu M., Huang W., Wang G., Zhu T., Zhang J, Zhu P.Changes of plasma vWF level in response to the improvement of air quality: an observation of 114 healthy young adults. Ann Hematol. 92(4), 543-548, 2013. View

Zhang J., Nazarenko Y., Zhang L., Calderon L., Lee K., Garfunkel E., Schwander S., Tetley T., Chung K.F., Porter A., Ryan M., Kipen P., Lioy P., Mainelis G. Impacts of a Nanosized Ceria Additive on Diesel Engine Emissions of Particulate and Gaseous Pollutants. Environment Science and Technology, 47 (22), 13077-13085, 2013. View

Chen S., Goode A., Sweeney S., Theodorou I., Thorley A., Ruenraroengsak P., Chang Y., Gow A., Schwander S., Zhang J., Shaffer M.S., Chung K.F., Tetley T.D., Ryan M.P., Porter A.E. Sulfidation of silver nanowires inside human alveolar epithelial cells: a potential detoxification mechanism. Nanoscale, 5(20):9839-47, 2013. View

Fen L.B., Chen S., Kyo Y., McPhail D.S., Shaffer M.S., Schwander S., Gow A., Zhang J., Chung K.F., Tetley T.D., Porter A.E., Ryan M.P. The Stability of Silver Nanoparticles in a Model of Pulmonary Surfactant. Environment Science and Technology,47(19):11232-11240, 2013. View

Commodore A.A., Zhang J., Chang Y., Hartinger S.M., Lanata C.F., Mausezahl D., Gil A.I., Hall D.B., Aguilar-Villalobos M., Vena J.E., Wang J-S., Naeher L.P. Concentrations of Urinary 8-Hydroxy-2'-deoxyguanosine and 8-isoprostane in Women Exposed to Woodsmoke in a Cookstove Intervention Study in San Marcos, Peru. Environment International, 60:112-122, 2013. View

Adetona O., Zhang J., Hall D.B., Wang J-S., Vena J.E., Naeher L.P. Occupational Exposure to Woodsmoke and Oxidative Stress in Wildland Firefighters. Science of the Total Environment, 449:269-275,2013. View

Rich D.Q., Ozkaynak H., Crooks J., Baxter L, Burke J., Ohman-Strickland P., Thevenet Morrison K., Kipen H.M., Zhang J., Kostis J., Lunden M., Hodas N., Turpin B. The triggering of myocardial infarction by fine particles is enhanced when particles are enriched secondary species. Environmental Science and Technology, 47(16):9414-23, 2013. View

Mapou A.E.M., Shendell D.G., Therkorn J.H., Xiong Y., Meng Q., Zhang J. Aldehydes in Passenger Vehicles: An analysis of data from the RIOPA Study 1999-2001. Atmospheric Environment 79:751-759, 2013. View

Gong J., Zhu T., Kipen H.M., Wang G., Hu M., Ohman-Strickland P., Lu S.E., Zhang L., Wang Y., Zhu P., Rich D.Q., Diehl S.R., Huang W., Tong J., Zhang J. Malondialdehyde in Exhaled Breath Condensate and Urine as a Biomarker of Air Pollution Induced Oxidative stress. Journal Of Exposure Science And Environmental Epidemiology, 23(3):322-7, 2013. View

Royce G.S., Dwaipayan M., Cai Ting., Xu, S.S., Alexander J.A., Mi, Z., Calderon G.M., Lee K.B., Lioy, P.J., Tetley T.D., Chung, K.F., Zhang J., Georgopoulos, P.G.,Modeling Population Exposures to Silver Nanoparticles Present in Consumer Products. J. Nano Res. DOI:10.1007/s11051-014-2724-4 (in press). View

Chang C., Nguyen C., Paranjpe V.R., Gilliland F., Zhang J., Analysis of Bispherol, a Diglycidyl Ether (BADGE) and its Hydrolytic Metabolites in Biological Specimens by High-Performance Liquid Chromatography Tendem Mass Spectrometry. View