William Richardson
Professor of Orthopaedic Surgery
Professor in Neurosurgery
Affiliate, Duke Global Health Institute
Appointment:
Countries:
William Richardson
Professor of Orthopaedic Surgery
Professor in Neurosurgery
Affiliate, Duke Global Health Institute
Research interests include:
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Current research includes investigation of biomechanical aspects of cervical injury with head impact. This involves cadaveric work with high-speed photography and load cells to ascertain the mechanism for spinal fractures.
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An animal model is being used to evaluate the biomechanics of cervical laminectomy versus laminoplasty compared to the normal spine. A portion of the animals are developing myelopathy secondary to instability after the surgical procedure and this is being evaluated with MRI scanning as well as mechanical and radiographic testing.
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Studies are being performed to develop an impedance pedicle probe to aid safe insertion of pedicular instrumentation in the lumbar spine. Ongoing studies are being performed to define the optimal frequency for the probe to yield the most sensitive and specific device. Hopefully this will lead to development of a device for human use. Studies will compare impedance probe to currently used EMG techniques to see if combing them will lead to greater sensitivity and specificity.
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Studies are being completed on testing particular pull-out strength and doing a multi-varied analysis looking at size of the pedicle and bone density by two different techniques.
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Current work is ongoing to develop an outcomes instrument and database to be used in the outpatient setting for patients with spinal complaints, both cervical and lumbar. The device will be used to evaluate clinical effectiveness for a variety of treatments for spinal conditions and to look at patient satisfaction issues.
Publications
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Cottrill E, Pennington Z, Sattah N, Jing C, Salven D, Johnson E, et al. Gene Therapy and Spinal Fusion: Systematic Review and Meta-Analysis of the Available Data. World Neurosurg. 2024 Jun;186:219-234.e4.Bergin SM, Crutcher CL, Keeler C, Rocos B, Haglund MM, Michael Guo H, et al. Osteoimmunology: Interactions With the Immune System in Spinal Fusion. Int J Spine Surg. 2023 Dec 27;17(S3):S9–17.Bhenderu LS, Lyon KA, Soto JM, Richardson W, Desai R, Rahm M, et al. Ropivacaine-Epinephrine-Clonidine-Ketorolac Cocktail as a Local Anesthetic for Lumbar Decompression Surgery: A Single Institutional Experience. World Neurosurg. 2023 Aug;176:e515–20.Peer CJ, Schmidt KT, Arisa O, Richardson WJ, Paydary K, Goldstein DA, et al. In Silico Re-Optimization of Atezolizumab Dosing Using Population Pharmacokinetic Simulation and Exposure-Response Simulation. J Clin Pharmacol. 2023 Jun;63(6):672–80.
See more publications at Scholars@Duke