With the advancements in cancer treatment and early detection, cancer survival rates have seen a consistent increase, accompanied by a rise in the number of new cancer cases. A substantial portion of the 17 million individuals in the United States living with a cancer diagnosis confront pain and depression, stemming from either the cancer itself or cancer treatment. Despite the well-established connection between pain and depression, limited research exists on chronic pain, particularly high-impact chronic pain (HICP), within the population of cancer survivors. Utilizing nationally representative cross-sectional data obtained from the National Health Interview Survey (NHIS), this study investigates the prevalence and trends of chronic pain and HICP among cancer survivors over the period from 2010 to 2021. Furthermore, this research seeks to elucidate the association between chronic pain, HICP, and depression. The findings of this study hold the potential to enhance cancer care, specifically in the realms of pain management and mental health services, by providing insights into the intricate relationship between depression and chronic pain.