To successfully confront the SCD burden in high prevalence regions like Jamaica, researchers and local health systems must prioritize efforts to generate population-specific health data through genetics research and integrate novel technologies into patient care. While these efforts require local health and research infrastructure development, they also require the development of region-specific social and ethical frameworks. Therefore, research must be done to understand SCD stakeholder perspectives on, and the ethical, social and cultural implications of genetics research and cures for SCD within the Jamaican context.