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Faculty

Nathan Thielman

Professor, Medicine and Global Health
Director, Global Health Residency/Fellowship Pathway Program
Associate Director of Master of Science in Global Health
School of Medicine
Medicine: Infectious Diseases

Trent 201
(919) 668-7174
n.thielman@duke.edu

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Nathan Thielman

Summary

Dr. Thielman's research focuses on critical clinical and social issues that affect persons living with or at risk for HIV infection. In collaboration with colleagues in Tanzania and at the Center for Health Policy and Inequalities Research, his work seeks to understand key determinants of HIV testing behaviors in order to increase testing uptake in the Kilimanjaro Region and other resource poor regions. Additional research among longitudinal cohorts describes psychosocial, demographic, and economic characteristics that affect health outcomes of HIV-infected patients and children orphaned by AIDS. Domestically, he is Clinical Site Leader for Duke's Adult AIDS Clinical Trials Unit, and he is the Program Director for the Duke Global Health Residency/Fellowship Pathway .

Thielman is the recipient of the Duke Global Health Institute 2012 Excellence in Mentoring Award.

Projects

Recent Publications

Berry SM, Petzold EA, Dull P, Thielman NM, Cunningham CK, Corey GR, McClain MT, Hoover DL, Russell J, Griffiss JM, Woods CW (2016). A response adaptive randomization platform trial for efficient evaluation of Ebola virus treatments: A model for pandemic response. Clin Trials 13(1):22-30.

Brown JF, Rowe K, Zacharias P, van Hasselt J, Dye JM, Wohl DA, Fischer WA, 2nd, Cunningham CK, Thielman NM, Hoover DL (2016). Apheresis for collection of ebola convalescent plasma in Liberia. J Clin Apher.

Gray CL, Pence BW, Messer LC, Ostermann J, Whetten RA, Thielman NM, O'Donnell K, Whetten K (2016). Civic engagement among orphans and non-orphans in five low- and middle-income countries. Global Health 12(1):61. PMCID: PMC5057410.

Gray CL, Whetten K, Messer LC, Whetten RA, Ostermann J, O'Donnell K, Thielman NM, Pence BW (2016). Potentially traumatic experiences and sexual health among orphaned and separated adolescents in five low- and middle-income countries. AIDS Care:1-9.

Lewandowski LB, Schanberg LE, Thielman N, Phuti A, Kalla AA, Okpechi I, Nourse P, Gajjar P, Faller G, Ambaram P, Reuter H, Spittal G, Scott C (2016). Severe disease presentation and poor outcomes among pediatric systemic lupus erythematosus patients in South Africa. Lupus.

O'Donnell JK, Gaynes BN, Cole SR, Edmonds A, Thielman NM, Quinlivan EB, Shirey K, Heine AD, Modi R, Pence BW (2016). Ongoing life stressors and suicidal ideation among HIV-infected adults with depression. J Affect Disord 190:322-8. PMCID: PMC4685465.

Ramadhani HO, Bartlett JA, Thielman NM, Pence BW, Kimani SM, Maro VP, Mwako MS, Masaki LJ, Mmbando CE, Minja MG, Lirhunde ES, Miller WC (2016). The Effect of Switching to Second-Line Antiretroviral Therapy on the Risk of Opportunistic Infections Among Patients Infected With Human Immunodeficiency Virus in Northern Tanzania. Open Forum Infect Dis 3(1):ofw018. PMCID: PMC4776054.

Reddy EA, Agala CB, Maro VP, Ostermann J, Pence BW, Itemba DK, Safley D, Yao J, Thielman NM, Whetten K (2016). Test site predicts HIV care linkage and antiretroviral therapy initiation: a prospective 3.5 year cohort study of HIV-positive testers in northern Tanzania. BMC Infect Dis 16:497. PMCID: PMC5028933.

Stanifer JW, Egger JR, Turner EL, Thielman N, Patel UD, Comprehensive Kidney Disease Assessment for Risk factors eK, Attitudes S (2016). Neighborhood clustering of non-communicable diseases: results from a community-based study in Northern Tanzania. BMC Public Health 16(1):226. PMCID: PMC4779220.

Stanifer JW, Turner EL, Egger JR, Thielman N, Karia F, Maro V, Kilonzo K, Patel UD, Yeates K (2016). Knowledge, Attitudes, and Practices Associated with Chronic Kidney Disease in Northern Tanzania: A Community-Based Study. PLoS ONE 11(6):e0156336.

Thielman NM, Cunningham CK, Woods C, Petzold E, Sprenz M, Russell J (2016). Ebola clinical trials: Five lessons learned and a way forward. Clin Trials 13(1):83-6.

Stanifer JW, Patel UD, Karia F, Thielman N, Maro V, Shimbi D, Kilaweh H, Lazaro M, Matemu O, Omolo J, Boyd D, Comprehensive Kidney Disease Assessment for Risk factors eK, Attitudes S (2015). The determinants of traditional medicine use in northern Tanzania: a mixed-methods study. PLoS ONE 10(4):e0122638.

Stanifer JW, Maro V, Egger J, Karia F, Thielman N, Turner EL, Shimbi D, Kilaweh H, Matemu O, Patel UD (2015). The epidemiology of chronic kidney disease in Northern Tanzania: a population-based survey. PLoS ONE 10(4):e0124506. PMCID: PMC4401757.

Pence BW, Quinlivan EB, Heine A, Edwards M, Thielman NM, Gaynes BN (2015). When "need plus supply" does not equal demand: challenges in uptake of depression treatment in HIV clinical care. Psychiatr Serv 66(3):321-3. PMCID: PMC4381922.

Pence BW, Gaynes BN, Thielman NM, Heine A, Mugavero MJ, Turner EL, Quinlivan EB (2015). Balancing Contamination and Referral Bias in a Randomized Clinical Trial: An Application of Pseudo-Cluster Randomization. Am J Epidemiol.

Pence BW, Gaynes BN, Adams JL, Thielman NM, Heine AD, Mugavero MJ, McGuinness T, Raper JL, Willig JH, Shirey KG, Ogle M, Turner EL, Quinlivan EB (2015). The effect of antidepressant treatment on HIV and depression outcomes: results from a randomized trial. AIDS 29(15):1975-86.

Ostermann J, Pence B, Whetten K, Yao J, Itemba D, Maro V, Reddy E, Thielman N (2015). HIV serostatus disclosure in the treatment cascade: evidence from Northern Tanzania. AIDS Care 27(sup1):59-64.

Ostermann J, Njau B, Mtuy T, Brown DS, Muhlbacher A, Thielman N (2015). One size does not fit all: HIV testing preferences differ among high-risk groups in Northern Tanzania. AIDS Care 27(5):595-603. PMCID: PMC4336601.

Ostermann J, Brown DS, Muhlbacher A, Njau B, Thielman N (2015). Would you test for 5000 Shillings? HIV risk and willingness to accept HIV testing in Tanzania. Health Econ Rev 5(1):60. PMCID: PMC4540717.

Gray CL, Pence BW, Ostermann J, Whetten RA, O'Donnell K, Thielman NM, Whetten K (2015). Prevalence and Incidence of Traumatic Experiences Among Orphans in Institutional and Family-Based Settings in 5 Low- and Middle-Income Countries: A Longitudinal Study. Glob Health Sci Pract 3(3):395-404. PMCID: PMC4570014.

Gray CL, Pence BW, Ostermann J, Whetten RA, O'Donnell K, Thielman NM, Whetten K (2015). Gender (in) differences in prevalence and incidence of traumatic experiences among orphaned and separated children living in five low- and middle-income countries. Glob Ment Health 2. PMCID: 4467827.

Bengtson AM, Pence BW, O'Donnell J, Thielman N, Heine A, Zinski A, Modi R, McGuinness T, Gaynes B (2015). Improvements in depression and changes in quality of life among HIV- infected adults. AIDS Care 27(1):47-53. PMCID: PMC4402235.

Barroso J, Bengtson AM, Gaynes BN, McGuinness T, Quinlivan EB, Ogle M, Heine A, Thielman NM, Pence BW (2015). Improvements in Depression and Changes in Fatigue: Results from the SLAM DUNC Depression Treatment Trial. AIDS Behav.

Whetten K, Ostermann J,Pence BW,Whetten RA,Messer LC, Ariely S,O'Donnell K, Wasonga AI, Vann V, Itemba D,Eticha M, Madan I, Thielman NM, Positive Outcomesfor Orphans Research T (2014).Three-year change in thewell-being of orphaned andseparated children in institutionaland family-based care settings infive low-and middle-income countries. PLoS ONE 9(8):e104872.PMCID: PMC4146542

Thielman NM, Ostermann J, Whetten K, Whetten R, Itemba D, Maro V, Pence B, Reddy E, Team CR (2014). Reduced Adherence to Antiretroviral Therapy Among HIV-Infected Tanzanians Seeking Cure From the Loliondo Healer. J. Acquir. Immune Defic. Syndr. 65(3):e104-9.

Reddy EA, Njau BN, Morpeth SC, Lancaster KE, Tribble AC, Maro VP, Msuya LJ, Morrissey AB, Kibiki GS, Thielman NM, Cunningham CK, Schimana W, Shao JF, Chow S-C, Stout JE, Crump JA, Bartlett JA, Hamilton CD (2014). A randomized controlled trial of standard versus intensified tuberculosis diagnostics on treatment decisions by physicians in Northern Tanzania. BMC Infect Dis 14(1):89.

Ostermann J, Njau B, Brown DS, Mühlbacher A, Thielman N (2014). Heterogeneous HIV Testing Preferences in an Urban Setting in Tanzania: Results from a Discrete Choice Experiment. PLoS ONE 9(3):e92100. Epub 2014/03/20. doi: 10.1371/journal.pone.0092100. PubMed PMID: 24643047.

Sumner SA, Pallangyo AJ, Reddy EA, Maro V, Pence BW, Lynch C, Turner EL, Egger JR, Thielman NM (2014). Effect of free distribution of safety equipment on usage among motorcycle-taxi drivers in Tanzania-A cluster randomised controlled trial. Injury. doi: 10.1016/j.injury.2014.04.034. PubMed PMID: 24861418.

O'Donnell K, Yao J, Ostermann J, Thielman N, Reddy E, Whetten R, Maro V, Itemba D, Pence B, Dow D, Whetten K (2014). Low rates of child testing for HIV persist in a high-risk area of East Africa. AIDS Care 26(3):326-31.

Ostermann J, Whetten K, Reddy E, Pence B, Weinhold A, Itemba D, Maro V, Mosille E, Thielman N, The CRT (2014). Treatment retention and care transitions during and after the scale-up of HIV care and treatment in Northern Tanzania. AIDS Care. Epub 2014/02/13. doi: 10.1080/09540121.2014.882493. PubMed PMID: 24517083.

Ramadhani HO, Bartlett JA, Thielman NM, Pence BW, Kimani SM, Maro VP, Mwako MS, Masaki LJ, Mmbando CE, Minja MG, Lirhunde ES, Miller WC (2014). Association of First-Line and Second-Line Antiretroviral Therapy Adherence. Open Forum Infectious Diseases 1(2):ofu079-ofu. doi: 10.1093/ofid/ofu079.

Okeke NL, Ostermann J, Thielman NM (2014). Enhancing Linkage and Retention in HIV Care: a Review of Interventions for Highly Resourced and Resource-Poor Settings. Curr HIV/AIDS Rep 11(4):376-92. doi: 10.1007/s11904-014-0233-9. PubMed PMID: 25323298.

Thielman NM, Ostermann J, Whetten K, Whetten R, Itemba D, Maro V, Pence B, Reddy E (2014). Reduced adherence to antiretroviral therapy among HIV-infected Tanzanians seeking cure from the Loliondo healer. J Acquir Immune Defic Syndr 65(3):e104-9. Epub 2014/02/15. doi: 10.1097/01.qai.0000437619.23031.83. PubMed PMID: 24525471; PubMed Central PMCID: PMCPmc4006017.

Njau B, Ostermann J, Brown D, Muhlbacher A, Reddy E, Thielman N (2014). HIV testing preferences in Tanzania: a qualitative exploration of the importance of confidentiality, accessibility, and quality of service. BMC Public Health 14:838. Epub 2014/08/16. doi: 10.1186/1471-2458-14-838. PubMed PMID: 25124140; PubMed Central PMCID: PMCPmc4141951.

Ostermann J, Whetten K, Reddy E, Pence B, Weinhold A, Itemba D, Maro V, Mosille E, Thielman N (2014). Treatment retention and care transitions during and after the scale-up of HIV care and treatment in Northern Tanzania. AIDS Care 26(11):1352-8. Epub 2014/02/13. doi: 10.1080/09540121.2014.882493. PubMed PMID: 24517083; PubMed Central PMCID: PMCPmc4122642.

O'Donnell K, Yao J, Ostermann J, Thielman N, Reddy E, Whetten R, Maro V, Itemba D, Pence B, Dow D, Whetten K (2014). Low rates of child testing for HIV persist in a high-risk area of East Africa. AIDS Care 26(3):326-31. Epub 2013/07/24. doi: 10.1080/09540121.2013.819405. PubMed PMID: 23875966.

O'Donnell, K., Yao, J., Ostermann, J., Thielman, N., Reddy, E., Whetten, R., et al. (2013). Low rates of child testing for HIV persist in a high-risk area of East Africa. AIDS Care, 1-6. doi:10.1080/09540121.2013.819405

Thielman, N. M., Ostermann, J., Whetten, K., Whetten, R., Itemba, D., Maro, V., et al. (2013). Reduced Adherence to Antiretroviral Therapy among HIV-infected Tanzanians Seeking Cure from the Loliondo Healer. JAIDS Journal of Acquired Immune Deficiency Syndromes, in press. doi:10.1097/01.qai.0000437619.23031.83

Sumner, S. A., Turner, E. L., & Thielman, N. M. (2013). Association Between Earthquake Events and Cholera Outbreaks: A Cross-country 15-year Longitudinal Analysis. Prehosp Disaster Med, 28(6):567-72. doi:10.1017/S1049023X13008984

Bess KD, Adams J, Watt MH, O'Donnell JK, Gaynes BN, Thielman NM, Heine A, Zinski A, Raper JL, & Pence BW. Providers' attitudes towards treating depression and self-reported depression treatment practices in HIV outpatient care. AIDS Patient Care and STDs, 27(3), 171-180, 2013.

Homaifar N, Mwesigye D, Tchwenko S, Worjoloh A, Joharifard S, Kyamanywa P, Wilkinson J, Rulisa S, Thielman NM. Emergency obstetrics knowledge and practical skills retention among medical students in Rwanda following a short training course. Int J Gynaecol Obstet. 2013 Feb;120(2):195-9

Joharifard S, Rulisa S, Niyonkuru F, Weinhold A, Sayinzoga F, Wilkinson J, Ostermann J, Thielman NM. Prevalence and predictors of giving birth in health facilities in Bugesera District, Rwanda. BMC Public Health. 2012 Dec 5;12:1049

Thielman N, Ostermann J, Whetten K, Whetten R, O'Donnell K. Correlates of poor health among orphans and abandoned children in less wealthy countries: The importance of caregiver health. PLoS One 7(6):e38109, 2012.

Casey ER, Muro F, Thielman NM, Maya E, Ossmann EW, Hocker MB, Gerardo CJ. Analysis of traumatic injuries presenting to a referral hospital emergency department in Moshi, Tanzania. Int J Emerg Med 5(1):28, 2012.

Fiorillo SP, Landman KZ, Tribble AC, Mtalo A, Itemba DK, Ostermann J, Thielman NM, Crump JA. Changes in HIV risk behavior and seroincidence among clients presenting for repeat HIV counseling and testing in Moshi, Tanzania. AIDS Care 24(10):1264-71, 2012.

Pence BW, Gaynes BN, Williams Q, Modi R, Adams J, Quinlivan EB, Heine A, Thielman N, Mugavero MJ. Assessing the effect of Measurement-Based Care depression treatment on HIV medication adherence and health outcomes: Rationale and design of the SLAM DUNC Study. Contemp Clin Trials 33 (4):828-38, 2012.

Pence, BW, Mugavero, MJ, Carter, TJ, Leserman, J., Thielman, NM, Raper, JL, Proeschold-Bell, RJ, Reif, S, Whetten, K. Childhood trauma and health outcomes in HIV-infected patients: an exploration of causal pathways, J Acquir Immune Defic Syndr 59(4):409-16, 2012.

Puri, R, Rulisa, S, Joharifard, S, Wilkinson, J, Kyamanywa, P, Thielman, N. Knowledge, attitudes and practices in safe motherhood care among obstetric providers in Bugesera District, Rwanda. Int J Gynaecol Obstet 16(2):124-7, 2012

O'Donnell K, Murphy R, Ostermann J, Masnick M, Whetten RA, Madden E, Thielman NM, Whetten K, The Positive Outcomes for Orphans (POFO) Research Team. A brief assessment of learning for orphaned and abandoned Children in low and middle income countries. AIDS Behav 16(2):480-90, 2012.