Nitric Oxide and Microvascular Dysfunction in Severe Malaria
This R01 research project funded by NHLBI aims to understand whether disruption of the matrix that lines human vascular endothelium, glycocalyx, is a determinant of the vascular dysfunction observed in severe falciparum malaria. The research project will also conduct phase I studies of medical adjuvant therapies for malaria: administration of a nitric oxide donor molecule to assess whether this ameliorates the vascular dysfunction observed in severe falciparum malaria.
**Aim 1.** We will determine the relationship between endothelial glycocalyx breakdown, endothelial NO bioavailability & function, and malaria disease severity.
**Aim 2.** Determine if children with falciparum malaria have vascular responses to exogenous NO (nitrite) and how this relates to glycocalyx integrity.
Could inform development of adjuvant therapies for severe falciparum malaria.