This mixed-methods study sought to evaluate the feasibility of noninvasive intracranial pressure monitoring for adults after traumatic brain injury in Uganda using pupillometry, a handheld, automated device that measures the pupil response to light. Additionally, this study sought to assess the feasibility of conducting follow-up clinical research. The project was completed in the neurosurgery ward, emergency ward, and clinical laboratories at Mulago National Referral Hospital in Kampala, Uganda. Providers at Mulago National Referral Hospital received education and hands-on training on pupillometry and intracranial pressure monitoring, completed interviews to assess their perception of the device and thoughts on implementation, and engaged in a focus group discussion of their perspectives on research design at their hospital. Additionally, a chart review was completed to assess the frequency of documentation of clinical variables in the charts of neurosurgery patients with traumatic brain injury.