Margaret Humphreys' research interests include the history of American medicine and public health, history of tropical medicine, history of medicine in the American Civil War and history of racial disparities in health and health care in the United States, and infectious disease in the U.S. and the American South.
Her research has appeared in a wide range of academic journals, and she has published several books, including her most recent, Marrow of Tragedy: The Health Crisis of the American Civil War. Humphreys was editor in chief of the Journal of the History of Medicine and Allied Sciences from 1999 to 2012.
Humphreys, a professor in the Duke School of Medicine, is the president of the American Association for the History of Medicine. She also serves on the advisory board of the Triangle Center for Evolutionary Medicine.