L Gayani Tillekeratne
Associate Professor of Medicine
Associate Research Professor of Global Health
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L Gayani Tillekeratne
Associate Professor of Medicine
Associate Research Professor of Global Health
Gayani Tillekeratne, MD MSc is an Associate Professor in the Division of Infectious Diseases and at the Duke Global Health Institute. Her work focuses on improving the diagnosis and management of acute febrile and acute respiratory tract infections globally, with the goal of improving antimicrobial use for these infections.
Her activities include 1) epidemiological studies that describe the etiology and seasonality of infections such as influenza, SARS-CoV-2, dengue, and leptospirosis, 2) translational studies to develop novel host response-based diagnostics (transcriptomics based) that differentiate bacterial versus viral infections, 3) clinical trials on the implementation of diagnostics and vaccines for infectious diseases, and 4) the assessment of feasibility, acceptability, and cost-effectiveness of interventions in low-resource settings.
She is co-director of the Ruhuna-Duke Centre for Infectious Diseases in Sri Lanka and collaborates with colleagues in Southeast Asia, East Africa, and the US. She is co-leader for the Bass Connections program 'Antimicrobial Resistance in a Changing Climate: One Health Policy Framework.'
Projects
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ACTIV-1 (COVID-19 therapeutic trial)
United States
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RADx-UP CDCC (COVID-19 diagnostics)
United States
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Partnership for Enhancing Antimicrobial Use in Resource-Limited Settings (PEARL)
Kenya, Sri Lanka, Tanzania
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Surveillance for severe dengue in southern Sri Lanka
Sri Lanka
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Novel Diagnostics to Improve Antimicrobial Stewardship for Acute Respiratory Tract Infections in Resource-Limited Settings
Sri Lanka
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A One Health approach to antibiotic-resistant Enterobacteriaceae in South Asia
Sri Lanka
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Antibiotic-resistant Enterobacteriaceae in community-acquired urinary tract infections, southern Sri Lanka
Sri Lanka
Publications
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K Bodinayake C, De S Nagahawatte A, de Silva V, Ariyananda PL, Perera B, Kurukulasooriya R, et al. Academic global health collaboration: the Ruhuna-Duke partnership. Glob Health Action. 2025 Dec;18(1):2543603.Phan PT, Wijayaratne G, Bodinayake CK, Oguzie JU, Nguyen-Tien T, Marushchak LV, et al. Diverse respiratory viruses detected among hospitalized patients with pneumonia in Sri Lanka and Vietnam. IJID Reg. 2025 Dec;17:100757.Weishampel ZA, Nagahawatte A, Wijayaratne G, Wickramasinghe SS, Nicholson B, Anderson J, et al. Use of the BIOFIRE® FILMARRAY® Pneumonia plus Panel to characterize the etiology of lower respiratory tract infections among hospitalized patients in Southern Province, Sri Lanka. BMC Infect Dis. 2025 Sep 29;25(1):1178.De Zoysa W, Palangasinghe D, Bodinayake C, Nagahawatte A, Gamage J, Iglesias-Ussel MD, et al. Electronic Clinical Decision Support Tools to Manage Patients with Lower Respiratory Tract Infection: Clinicians' Perspectives in Sri Lanka. Am J Trop Med Hyg. 2025 May 7;112(5):1168–74.
See more publications at Scholars@Duke

