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Michael Haglund

Professor of Surgery, Neurobiology and Global Health
School of Medicine
Surgery: Neurosurgery

(919) 684-6936

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Michael Haglund


Clinically, my areas of subspecialty in neurosurgery includes the surgical treatment of epilepsy and functional mapping for resection of brain tumors. The major areas of research include: the cortical organization of higher cognitive functions as well as the mechanisms and pathways underlying the propagation of seizure activity. Research into the cortical organization of higher cognitive functions include language organization, memory and face processing involving electrical stimulation mapping in patients undergoing awake craniotomies and the use of optical imaging to localize areas of the neocortex serving specific cognitive processes. The mechanisms underlying the pathways and propagation of seizures involves using two models. The in vivo model, primate visual cortex, provides access to understanding the functional organization of the primate visual cortex and how seizure activity spreads through these known pathways. The pathways are investigated using microelectrode recordings as well as optical imaging. The second model, an in vitro slice preparation, involves using both rat and human neocortical slices. Propagation of seizure activity through normal pathways is studied using intracellular and extracellular electrode recording which is combined with optical imaging of the normal activity and abnormal seizure activity propagation. By better understanding how the normal cortex in humans is organized and how abnormal activity such as seizures is propagated, improvements in the surgical treatment of epilepsy will be accomplished. Other areas of interests include the use of dynamic optical imaging to study the grading and localization of intrinsic brain tumors. As one of the authors on two U.S. patents which involves this technique, the ability to study brain tumors and other tumors not involving the brain using optical imaging may improve our ability to obtain more complete resections and to noninvasively screen and monitor many types of tumors.


Recent Publications

Farber SH, Vissoci JR, Tran TM, Fuller AT, Butler EK, Andrade L, Staton C, Makumbi F, Luboga S, Muhumuza C, Namanya DB, Chipman JG, Galukanda M, Haglund MM. Geospatial Analysis of Unmet Surgical Need in Uganda: An Analysis of SOSAS Survey Data. World J Surg. 2016.

Tran TM, Fuller AT, Butler EK, Makumbi F, Luboga S, Muhumuza C, Ssennono VF, Chipman JG, Galukande M, Haglund MM. Burden of Surgical Conditions in Uganda: A Cross-sectional Nationwide Household Survey. Ann Surg. 2016.

Butler EK, Tran TM, Fuller AT, Brammell A, Vissoci JR, Andrade LD, Makumbi F, Luboga S, Muhumuza C, Ssennono VF, Chipman JG, Galukande M, Haglund MM, Smith ER. Quantifying the pediatric surgical need in Uganda: results of a nationwide cross-sectional, household survey. Pediatr Surg Int. 2016.

Fuller A, Butler E, Tran T, Makumbi F, Luboga S, Muhumuza C, Chipman J, Groen R, Gupta S, Kushner A, Galukande M, Haglund M.Surgeons OverSeas Assessment of Surgical Need (SOSAS) Uganda: update for household survey. World Journal of Surgery 2015 Dec, 39(12): 2900-7.

Fuller A, Tran T, Muhumuza, M, Haglund MM. Building Neurosurgical capacity in low and middle income countries. Published online: November 3, 2015, eNeurologicalSci. June 2016.

Butler E, Tran T, Fuller A, Makumbi F, Luboga S, Kisakye S, Haglund M, Chipman J, Galukande M. Burden of Surgical Conditions in Uganda: Pilot Study of a Population-Based Survey in Wakiso District, Uganda.In Press Surgery 2015.

Tran TM, Fuller AT, Kiryabwire J, Mukasa J, Muhumuza M, Ssenyojo H, Haglund MM. Distribution and characteristics of severe traumatic brain injury at Mulago National Referral Hospital in Uganda. World Neurosurg. 2014 Dec 18. pii: S1878-8750(14)01399-0. doi: 10.1016/j.wneu.2014.12.028. [Epub ahead of print] PMID: 25529531

Hatef J, Adamson C, Obiga O, Taremwa B, Ssenyojo H, Muhumuza M, Haglund M, Schroeder K Central Nervous System Tumor Distribution at a Tertiary Referral Center in Uganda. World Neurosurg. 2014 Jun 19. pii: S1878-8750(14)00586-5. doi: 10.1016/j.wneu.2014.06.040. [Epub ahead of print] PMID: 24953304

Babu R, Thomas S, Hazzard MA, Lokhnygina YV, Friedman AH, Gottfried ON, Isaacs RE, Boakye M, Patil CG, Bagley CA, Haglund MM, Lad SP. Morbidity, mortality, and health care costs for patients undergoing spine surgery following the ACGME resident duty-hour reform. Journal of Neurosurgery: Spine 0:0, 1-14. PMID: 24995600

Babu R, Thomas S, Hazzard MA, Friedman AH, Sampson JH, Adamson C, Zomorodi AR, Haglund MM, Patil CG, Boakye M, Lad SP. Worse outcomes for patients undergoing brain tumor and cerebrovascular procedures following the ACGME resident duty-hour restrictions. Journal of Neurosurgery 121:2, 262-276. . Online publication date: 1-Aug-2014. PMID: 24926647

Serafini S, Komisarow JM, Gallentine W, Mikati MA, Bonner MJ, Kranz PG, Haglund MM, Grant G. 24961623Reorganization and stability for motor and language areas using cortical stimulation: case example and review of the literature. Brain Sci. 2013 Nov 26;3(4):1597-614. doi: 10.3390/brainsci3041597. PMID: 24961623

Serafini S, Clyde M, Tolson M, Haglund MM. Multimodality word-finding distinctions in cortical stimulation mapping. Neurosurgery. 2013 Jul;73(1):36-47. PMID: 23615091

Fontanella AN, Schroeder T, Hochman DW, Chen RE, Hanna G, Haglund MM, Secomb TW, Palmer GM, Dewhirst MW. Quantitative mapping of hemodynamics in the lung, brain, and dorsal window chamber-grown tumors using a novel, automated algorithm. Microcirculation. 2013 [Epub ahead of print] PMID: 23781901

Haglund MM. Optical imaging of visual cortex epileptic foci and propagation pathways.Epilepsia. 2012 Jun;53 Suppl 1:87-97. PMID:22612813

Fuller AT, Haglund MM, Lim S, Mukasa J, Muhumuza M, Kiryabwire J, Ssenyonjo H, Smith ER. Pediatric Neurosurgical Outcomes Following a Neurosurgery Health System Intervention at Mulago National Referral Hospital in Uganda. World Neurosurg. 2016;95:309-314.